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1.14.13.32: albendazole monooxygenase

This is an abbreviated version!
For detailed information about albendazole monooxygenase, go to the full flat file.

Reaction

albendazole
+
NADPH
+
H+
+
O2
=
albendazole S-oxide
+
NADP+
+
H2O

Synonyms

albendazol sulfoxidase, albendazole oxidase, albendazole sulfoxidase, lancet fluke NADPH-dependent sulphoxidizing enzyme

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.32 albendazole monooxygenase

Substrates Products

Substrates Products on EC 1.14.13.32 - albendazole monooxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 albendazole + 2 NADPH + 2 H+ + 2 O2
(+)-albendazole s-oxide + (-)-albendazole s-oxide + 2 NADP+ + 2 H2O
show the reaction diagram
albendazole + NADPH + H+ + O2
albendazole S-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
albendazole + NADPH + O2
(+)-albendazole S-oxide + NADP+
show the reaction diagram
albendazole + NADPH + O2
albendazole S-oxide + NADP+ + H2O
show the reaction diagram
albendazole S-oxide + NADP+ + H2O
albendazole + NADPH + H+ + O2
show the reaction diagram
-
-
-
-
r
additional information
?
-
-
intestinal bioconversion of the anthelmintic drug albendazole into albendazole sulfoxide by two enzymatic systems, cytochrome P4503A and flavin-containing monooxygenases, overview
-
-
?