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1.14.13.32: albendazole monooxygenase

This is an abbreviated version!
For detailed information about albendazole monooxygenase, go to the full flat file.

Reaction

albendazole
+
NADPH
+
H+
+
O2
=
albendazole S-oxide
+
NADP+
+
H2O

Synonyms

albendazol sulfoxidase, albendazole oxidase, albendazole sulfoxidase, lancet fluke NADPH-dependent sulphoxidizing enzyme

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.32 albendazole monooxygenase

Purification

Purification on EC 1.14.13.32 - albendazole monooxygenase

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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Dicrocoelium dendriticum adults are washed and homogenized in 0.1 M sodium phosphate buffer, pH 7.4, with Potter-Elvehjem homogenizer and sonicator, ultracentrifugation separates mitochondrial fraction (resuspended in 0.1 M sodium phosphate buffer, pH 7.4) from microsome fraction (resuspended in the same buffer containing 20% glycerol), and cytosol fraction
-