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1.14.13.233: 4-hydroxy-6-methylpretetramide 12a-monooxygenase

This is an abbreviated version!
For detailed information about 4-hydroxy-6-methylpretetramide 12a-monooxygenase, go to the full flat file.

Reaction

4-hydroxy-6-methylpretetramide
+
NADPH
+
H+
+
O2
=
4-de(dimethylamino)-4-oxoanhydrotetracycline
+
NADP+
+
H2O

Synonyms

oxyL

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.233 4-hydroxy-6-methylpretetramide 12a-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.233 - 4-hydroxy-6-methylpretetramide 12a-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
4-hydroxy-6-methylpretetramide,NADPH:oxygen oxidoreductase (12a-hydroxylating)
Contains FAD. The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. The enzyme is bifunctional, and can also catalyse EC 1.14.13.232, 6-methylpretetramide 4-monooxygenase.