1.14.13.232: 6-methylpretetramide 4-monooxygenase
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For detailed information about 6-methylpretetramide 4-monooxygenase, go to the full flat file.
Reaction
Synonyms
OxyE, oxyL
ECTree
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Systematic Name
Systematic Name on EC 1.14.13.232 - 6-methylpretetramide 4-monooxygenase
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6-methylpretetramide,NADPH:oxygen oxidoreductase (4-hydroxylating)
The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics. That bacterium possesses two enzymes that can catalyse the reaction - OxyE is the main isozyme, while OxyL has a lower activity. OxyL is bifunctional, and its main function is EC 1.14.13.233, 4-hydroxy-6-methylpretetramide 12a-monooxygenase. Contains FAD.