1.14.13.23: 3-hydroxybenzoate 4-monooxygenase

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For detailed information about 3-hydroxybenzoate 4-monooxygenase, go to the full flat file.

Reaction

Synonyms

3-hydroxybenzoate 4-hydroxylase, 3-hydroxybenzoate hydroxylase, 3-hydroxybenzoate-4-hydroxylase, 3HB4H, EC 1.14.99.13, FAD-dependent 4-hydroxybenzoate hydroxylase, m-hydroxybenzoate hydroxylase, MHBH, MobA, oxygenase, 3-hydroxybenzoate 4-mono-

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.23 3-hydroxybenzoate 4-monooxygenase

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Results	in table
2	Activating Compound
34	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
16	Cofactor
2	Crystallization (Commentary)
4	General Information
1	General Stability
14	Inhibitors
15	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
17	Organism
4	Pathway
2	PDB ID
3	pH Optimum
7	Protein Variants
3	Purification (Commentary)
3	Reaction
3	Reaction Type
15	Reference
3	Source Tissue
6	Specific Activity [micromol/min/mg]
32	Substrates and Products (Substrate)
6	Subunits
24	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 1.14.13.23 - 3-hydroxybenzoate 4-monooxygenase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4-chloromercuribenzoate

Comamonas testosteroni

Q6SSJ6

-

675418

4-hydroxy-3-iodomethylbenzoate

Comamonas testosteroni

-

inhibition not reversed in presence of dithiotreitol

390048

diethyldithiocarbamate

Aspergillus niger

-

-

438964

heavy metal ions

Aspergillus niger

-

-

438964

-

iodoacetamide

Comamonas testosteroni

-

inhibition reversed in presence of dithiotreitol

390048

m-Aminobenzoate

Aspergillus niger

-

-

438964

MobR

Comamonas testosteroni

-

a 42 kDa dimeric transcriptional regulator of the MarR family, encoded by an open reading frame mobR in the upstream region of mobA, binds to the target DNA and negatively regulates the expression of mobA, the repression is relieved by binding of 3-hydroxybenzoate, binding kinetics, overview

675417

-

N-ethylmaleimide

Aspergillus niger

-

-

438964

N-iodosuccinimide

Comamonas testosteroni

-

inhibition reversed in presence of dithiotreitol

390048

o-Iodosobenzoate

Comamonas testosteroni

-

inhibition reversed in presence of dithiotreitol

390048

o-phenanthroline

Aspergillus niger

-

-

438964

p-hydroxymercuribenzoate

Aspergillus niger

-

-

438964

Salicylaldoxime

Aspergillus niger

-

-

438964

additional information

Comamonas testosteroni

Q6SSJ6

MobR from Comamonas testosteroni KH122-3s is a member of the MarR family of transcriptional regulators, binds to DNA, and functions as a repressor for the mobA gene, that encodes a 3-hydroxybenzoate 4-hydroxylase, MobR is inactivated at a high concentration of 2,5-dihydroxybenzoate, 2,3-dihydroxybenzoate, 3-hydroxybenzoate and 3,5-dihydroxybenzoate

684868

-