1.14.13.225: F-actin monooxygenase

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For detailed information about F-actin monooxygenase, go to the full flat file.

Reaction

Synonyms

MICAL, MICAL-1, MICAL-2, MICAL1, Mical2, MICAL2PV, MICAL3

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.225 F-actin monooxygenase

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Results	in table
4	Activating Compound
5238	AA Sequence
2	Application
1	Cloned(Commentary)
7	Cofactor
3	Crystallization (Commentary)
165	Disease/ Diagnostics
10	General Information
2	Inhibitors
13	kcat/KM [mM/s]
16	KM Value [mM]
3	Localization
1	Metals/Ions
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
14	Organism
1	PDB ID
1	pH Optimum
5	Protein Variants
1	Purification (Commentary)
1	Reaction
14	Reference
8	Source Tissue
11	Substrates and Products (Substrate)
2	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
13	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.14.13.225 - F-actin monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

[F-actin]-L-methionine,NADPH:O2 S-oxidoreductase

The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization [1]. Free methionine is not a substrate [2]. The reaction is stereospecific and generates the (R)-sulfoxide [3]. In the absence of substrate, the enzyme can act as an NAD(P)H oxidase (EC 1.6.3.1) [4,5].