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1.14.13.225: F-actin monooxygenase

This is an abbreviated version!
For detailed information about F-actin monooxygenase, go to the full flat file.

Word Map on EC 1.14.13.225

Reaction

[F-actin]-L-methionine
+
NADPH
 +
O2
 +
H+
=
[F-actin]-L-methionine-(R)-S-oxide
 +
NADP+
 +
H2O

Synonyms

MICAL, MICAL-1, MICAL-2, MICAL1, Mical2, MICAL2PV, MICAL3

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.225 F-actin monooxygenase

Disease

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Disease on EC 1.14.13.225 - F-actin monooxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
Anthracosilicosis
[Cellular metabolism in nasal lining and buccal epithelium in coal miners]
Arrhythmias, Cardiac
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Breast Neoplasms
MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells.
MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway.
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation.
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Carcinogenesis
MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance.
Colorectal Neoplasms
MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance.
Epilepsy
Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
Epilepsy, Temporal Lobe
Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
Glioblastoma
MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
Latent Infection
Identification potential biomarkers in pulmonary tuberculosis and latent infection based on bioinformatics analysis.
Lentivirus Infections
MICAL2 regulates myofibroblasts differentiation in epidural fibrosis via SRF/MRTF-A signaling pathway.
Liver Cirrhosis
LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis.
Lymphatic Metastasis
MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
Melanoma
Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.
Myxoma
MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
Neoplasm Metastasis
Identification and expression analysis of mical family genes in zebrafish.
MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.
MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation.
Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT.
Neoplasms
Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling.
Deregulation of Rab and Rab effector genes in bladder cancer.
Development and clinical validation of a novel 9-gene prognostic model based on multi-omics in pancreatic adenocarcinoma.
Identification and expression analysis of mical family genes in zebrafish.
Identification of novel TGF-? regulated genes with pro-migratory roles.
MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways.
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
MICAL2 Facilitates Gastric Cancer Cell Migration via MRTF-A-Mediated CDC42 Activation.
MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.
MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation.
ORN: Inferring patient-specific dysregulation status of pathway modules in cancer with OR-gate Network.
Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT.
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.
Osteoarthritis
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3.
Prostatic Neoplasms
Actin Stimulates Reduction of the MICAL-2 Monooxygenase Domain.
Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.
Seizures
Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporal epilepsy and pilocarpine-induced rat model.
Spinal Cord Injuries
MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat.
MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury.
Stomach Neoplasms
MICAL2 Facilitates Gastric Cancer Cell Migration via MRTF-A-Mediated CDC42 Activation.
NEDD9 Facilitates Hypoxia-Induced Gastric Cancer Cell Migration via MICAL1 Related Rac1 Activation.