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1.14.13.223: 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase

This is an abbreviated version!
For detailed information about 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase, go to the full flat file.

Reaction

3-hydroxy-4-methylanthranilyl-[aryl-carrier protein]
+
NADH
+
H+
+
O2
=
3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein]
+
NAD+
+
H2O

Synonyms

sibG

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.223 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase

Systematic Name

Systematic Name on EC 1.14.13.223 - 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase

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SYSTEMATIC NAME
IUBMB Comments
3-hydroxy-4-methylanthranilyl-[aryl-carrier protein],NADH:oxygen oxidoreductase (5-hydroxylating)
A flavoprotein (FAD). The enzyme, characterized from the bacterium Streptosporangium sibiricum, is involved in the biosynthesis of the antitumor antibiotic sibiromycin. The enzyme is not active with free 3-hydroxy-4-methylanthranilate.