1.14.13.223: 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
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For detailed information about 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase, go to the full flat file.
Reaction
Synonyms
sibG
ECTree
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General Information
General Information on EC 1.14.13.223 - 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] 5-monooxygenase
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physiological function
biosynthesis of the antitumor antibiotic sibiromycin. Starting from 3-hydroxykynurenine, the SAM-dependent methyltransferase SibL converts the substrate to its 4-methyl derivative, followed by hydrolysis through the action of the PLP-dependent kynureninase SibQ, leading to 3-hydroxy-4-methylanthranilic acid formation. Subsequently the nonribosomal peptide synthetase SibE activates 3-hydroxy-4-methylanthranilic acid and tethers it to its thiolation domain, where it is hydroxylated at the C5 position by the FAD/NADH-dependent hydroxylase SibG yielding the fully substituted anthranilate moiety found in sibiromycin