1.14.13.222: aurachin C monooxygenase/isomerase

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For detailed information about aurachin C monooxygenase/isomerase, go to the full flat file.

Reaction

Synonyms

auaG, aurachin C monooxygenase, MimA, MimABCD, Msmeg_1971

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.222 aurachin C monooxygenase/isomerase

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Results	in table
26	AA Sequence
2	Cloned(Commentary)
5	Cofactor
4	General Information
2	Metals/Ions
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
6	Organism
3	Pathway
3	Reaction
6	Reference
9	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.14.13.222 - aurachin C monooxygenase/isomerase

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SYSTEMATIC NAME

IUBMB Comments

aurachin C:NAD(P)H:oxygen oxidoreductase (4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide-forming)

The aurachin C monooxygenase from the bacterium Stigmatella aurantiaca accepts both NADH and NADPH as cofactor, but has a preference for NADH. It catalyses the initial steps in the conversion of aurachin C to aurachin B. The FAD-dependent monooxygenase catalyses the epoxidation of the C2-C3 double bond of aurachin C, which is followed by a semipinacol rearrangement, causing migration of the farnesyl group from C3 to C4.