1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase

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For detailed information about tetracenomycin A2 monooxygenase-dioxygenase, go to the full flat file.

Reaction

Synonyms

ElmG, Tcm A2 oxygenase, Tcm B2 oxygenase, TcmG, tetracenomycin A2 oxygenase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase

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Results	in table
8	AA Sequence
5	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
1	General Information
3	KM Value [mM]
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
10	Organism
7	Pathway
2	pH Optimum
1	pH Range
1	pI Value
1	Purification (Commentary)
4	Reaction
8	Reference
1	Specific Activity [micromol/min/mg]
8	Substrates and Products (Substrate)
3	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.14.13.200 - tetracenomycin A2 monooxygenase-dioxygenase

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SYSTEMATIC NAME

IUBMB Comments

tetracenomycin A2,NAD(P)H:O2 oxidoreductase (tetracenomycin C forming)

Isolated from the bacterium Streptomyces glaucescens. The enzyme was also isolated from the bacterium Streptomyces olivaceus, where it acts on 8-demethyltetracenomycin A2 (tetracenomycin B2) as part of elloramycin biosynthesis. The reaction involves a monooxygenase reaction which is followed by a dioxygenase reaction giving a gem-diol and an epoxide. Water opens the epoxide giving two hydroxy groups. The gem-diol eliminates water to give a ketone which is then reduced to a hydroxy group.