1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase
This is an abbreviated version!
For detailed information about tetracenomycin A2 monooxygenase-dioxygenase, go to the full flat file.
Reaction
+ 2 O2 + 2 NAD(P)H + 2 H+ = + 2 NAD(P)+ +
Synonyms
ElmG, Tcm A2 oxygenase, Tcm B2 oxygenase, TcmG, tetracenomycin A2 oxygenase
ECTree
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Substrates Products
Substrates Products on EC 1.14.13.200 - tetracenomycin A2 monooxygenase-dioxygenase
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REACTION DIAGRAM
tetracenomycin A2 + 2 O2 + 2 NADH + 2 H+
tetracenomycin C + 2 NAD+ + H2O
tetracenomycin A2 i.e. methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate. The enzyme prefers NADPH over NADH as an electron donor
tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate
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tetracenomycin A2 + 2 O2 + 2 NADPH + 2 H+
tetracenomycin C + 2 NADP+ + H2O
tetracenomycin A2 i.e. methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate. The enzyme prefers NADPH over NADH as an electron donor
tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate
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tetracenomycin C + 2 NAD(P)+ + H2O
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enzyme is responsible for the hydroxylation of tetracenomycin A2 at positions C-4, C-4a, and C-12a to give tetracenomycin C
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tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+
tetracenomycin C + 2 NAD(P)+ + H2O
biosynthesis tetracenomycin C, a polyketide antitumor antibiotic
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tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+
tetracenomycin C + 2 NAD(P)+ + H2O
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quantitative conversion
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tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+
tetracenomycin C + 2 NAD(P)+ + H2O
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quantitative conversion
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8-demethyl tetracenomycin C + 2 NAD(P)+ + H2O
natural reaction in Streptomyces olivaceus
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tetracenomycin B2 + 2 O2 + 2 NAD(P)H + 2 H+
8-demethyl tetracenomycin C + 2 NAD(P)+ + H2O
natural reaction in Streptomyces olivaceus
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