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1.14.13.200: tetracenomycin A2 monooxygenase-dioxygenase

This is an abbreviated version!
For detailed information about tetracenomycin A2 monooxygenase-dioxygenase, go to the full flat file.

Reaction

tetracenomycin A2
+ 2 O2 + 2 NAD(P)H + 2 H+ =
tetracenomycin C
+ 2 NAD(P)+ +
H2O

Synonyms

ElmG, Tcm A2 oxygenase, Tcm B2 oxygenase, TcmG, tetracenomycin A2 oxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.200 tetracenomycin A2 monooxygenase-dioxygenase

Substrates Products

Substrates Products on EC 1.14.13.200 - tetracenomycin A2 monooxygenase-dioxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
tetracenomycin A2 + 2 O2 + 2 NAD(P)H + 2 H+
tetracenomycin C + 2 NAD(P)+ + H2O
show the reaction diagram
tetracenomycin A2 + 2 O2 + 2 NADH + 2 H+
tetracenomycin C + 2 NAD+ + H2O
show the reaction diagram
tetracenomycin A2 i.e. methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate. The enzyme prefers NADPH over NADH as an electron donor
tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate
-
?
tetracenomycin A2 + 2 O2 + 2 NADPH + 2 H+
tetracenomycin C + 2 NADP+ + H2O
show the reaction diagram
tetracenomycin A2 i.e. methyl 10,12-dihydroxy-3,8-dimethoxy-1-methyl-6,11-dioxo-6,11-dihydrotetracene-2-carboxylate. The enzyme prefers NADPH over NADH as an electron donor
tetracenomycin C = methyl (6aR,7S,10aR)-6a,7,10a,12-tetrahydroxy-3,8-dimethoxy-1-methyl-6,10,11-trioxo-6,6a,7,10,10a,11-hexahydrotetracene-2-carboxylate
-
?
tetracenomycin B2 + 2 O2 + 2 NAD(P)H + 2 H+
8-demethyl tetracenomycin C + 2 NAD(P)+ + H2O
show the reaction diagram