1.14.13.180: aklavinone 12-hydroxylase

This is an abbreviated version!
For detailed information about aklavinone 12-hydroxylase, go to the full flat file.

Reaction

Synonyms

aklavinone 12-hydroxylase, DnrF, RdmE

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.13.180 aklavinone 12-hydroxylase

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Results	in table
47	AA Sequence
1	Application
5	Cloned(Commentary)
5	Cofactor
2	Crystallization (Commentary)
2	General Information
2	Inhibitors
4	KM Value [mM]
3	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
10	Organism
5	Pathway
1	pH Optimum
1	pI Value
5	Protein Variants
1	Purification (Commentary)
1	Reaction
10	Reference
12	Substrates and Products (Substrate)
4	Subunits
11	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Reference

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Reference on EC 1.14.13.180 - aklavinone 12-hydroxylase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

721298

Hwang, C.K.; Kim, H.S.; Hong, Y.S.; Kim, Y.H.; Hong, S.K.; Kim, S.J.; Lee, J.J.

Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin

Antimicrob. Agents Chemother.

39

1616-1060

1995

Streptomyces peucetius

7492117

brenda

721697

Niemi, J.; Wang, Y.; Airas, K.; Ylihonko, K.; Hakala, J.; M�nts�l�, P.

Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens

Biochim. Biophys. Acta

1430

57-64

1999

Streptomyces purpurascens

10082933

brenda

722291

Wang, Y.; Niemi, J.; M�nts�l�, P.

Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products

FEMS Microbiol. Lett.

208

117-122

2002

Streptomyces purpurascens

11934504

brenda

722484

Hong, Y.S.; Hwang, C.K., Hong, S.K.; Kim, Y.H.; Lee, J.J.

Molecular cloning and characterization of the aklavinone 11-hydroxylase gene of Streptomyces peucetius subsp. caesius ATCC 27952

J. Bacteriol.

176

7096-7101

1994

Streptomyces peucetius (P72495), Streptomyces peucetius caesius ATCC 27952 (P72495)

7961477

brenda

722486

Niemi, J.; M�nts�l�, P.

Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus

J. Bacteriol.

177

2942-2945

1995

Streptomyces purpurascens

7751313

brenda

722958

Lindqvist, Y.; Koskiniemi, H.; Jansson, A.; Sandalova, T.; Schnell, R.; Liu, Z.; M�nts�l�, P.; Niemi, J.; Schneider, G.

Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis

J. Mol. Biol.

393

966-977

2009

Streptomyces purpurascens (Q54530)

19744497

brenda

723117

Filippini, S.; Solinas, M.M.; Breme, U.; Schl�ter, M.B.; Gabellini, D.; Biamonti, G.; Colombo, A.L.; Garofano, L.

Streptomyces peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression

Microbiology

141

1007-1016

1995

Streptomyces peucetius (P32009), Streptomyces peucetius ATCC 29050 (P32009)

7773378

brenda

764979

Yang, D.; Jang, W.D.; Lee, S.Y.

Production of carminic acid by metabolically engineered Escherichia coli

J. Am. Chem. Soc.

143

5364-5377

2021

Streptomyces peucetius (P32009), Streptomyces peucetius

33797895

brenda

Entries 1 - 20 of 8

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