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1.14.13.128: 7-methylxanthine demethylase

This is an abbreviated version!
For detailed information about 7-methylxanthine demethylase, go to the full flat file.

Word Map on EC 1.14.13.128

Reaction

7-methylxanthine
+
O2
+
NAD(P)H
+
H+
=
xanthine
+
NAD(P)+
+
H2O
+
formaldehyde

Synonyms

7-methylxanthine-specific N-demethylase, bacterial N-demethylase, caffeine demethylase, heteroxanthine demethylase, methylxanthine N-demethylase, N-demethylase, ndmA, NdmC, theobromine demethylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.128 7-methylxanthine demethylase

Reference

Reference on EC 1.14.13.128 - 7-methylxanthine demethylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Glück, M.; Lingens, F.
Heteroxanthinedemethylase, a new enzyme in the degradation of caffeine by Pseudomonas putida
Appl. Microbiol. Biotechnol.
28
59-62
1988
Pseudomonas putida
-
Manually annotated by BRENDA team
Summers, R.M.; Louie, T.M.; Yu, C.L.; Subramanian, M.
Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source
Microbiology
157
583-592
2011
Pseudomonas putida, Pseudomonas putida CBB5
Manually annotated by BRENDA team
Dash, S.S.; Gummadi, S.N.
Catabolic pathways and biotechnological applications of microbial caffeine degradation
Biotechnol. Lett.
28
1993-2002
2006
Pseudomonas putida
Manually annotated by BRENDA team
Summers, R.M.; Louie, T.M.; Yu, C.L.; Gakhar, L.; Louie, K.C.; Subramanian, M.
Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids
J. Bacteriol.
194
2041-2049
2012
Pseudomonas putida (M1EY73), Pseudomonas putida CBB5 (M1EY73), Pseudomonas putida CBB5
Manually annotated by BRENDA team
Summers, R.M.; Seffernick, J.L.; Quandt, E.M.; Yu, C.L.; Barrick, J.E.; Subramanian, M.V.
Caffeine junkie: an unprecedented glutathione S-transferase-dependent oxygenase required for caffeine degradation by Pseudomonas putida CBB5
J. Bacteriol.
195
3933-3939
2013
Pseudomonas putida (M1EY73), Pseudomonas putida CBB5 (M1EY73)
Manually annotated by BRENDA team
Algharrawi, K.; Summers, R.; Subramanian, M.
Production of theobromine by N-demethylation of caffeine using metabolically engineered E. coli
Biocatal. Agricult. Biotechnol.
11
153-160
2017
Pseudomonas putida (H9N289), Pseudomonas putida CBB5 (H9N289)
-
Manually annotated by BRENDA team
Retnadhas, S.; Gummadi, S.N.
Identification and characterization of oxidoreductase component (NdmD) of methylxanthine oxygenase system in Pseudomonas sp. NCIM 5235
Appl. Microbiol. Biotechnol.
102
7913-7926
2018
Pseudomonas sp. NCIM 5235 (A0A2U9IY60)
Manually annotated by BRENDA team
Kim, J.H.; Kim, B.H.; Brooks, S.; Kang, S.Y.; Summers, R.M.; Song, H.K.
Structural and mechanistic insights into caffeine degradation by the bacterial N-demethylase complex
J. Mol. Biol.
431
3647-3661
2019
Pseudomonas putida (M1EY73), Pseudomonas putida CBB5 (M1EY73), Pseudomonas putida CBB5
Manually annotated by BRENDA team