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1.14.13.101: senecionine N-oxygenase

This is an abbreviated version!
For detailed information about senecionine N-oxygenase, go to the full flat file.

Reaction

senecionine
+
NADPH
+
H+
+
O2
=
senecionine N-oxide
+
NADP+
+
H2O

Synonyms

flavin-dependent monooxygenase, fmoa, GgPNO, oxygenase, senecionine N-, PA N-oxygenase, PNO, pyrrolizidine alkaloid N-oxygenase, senecionine monooxygenase (N-oxide-forming), senecionine N-oxygenase, SNO, TjSNO, ZvFMOa, ZvPNO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
                1.14.13.101 senecionine N-oxygenase

Substrates Products

Substrates Products on EC 1.14.13.101 - senecionine N-oxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
atropine + NADPH + H+ + O2
atropine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
atropine + NADPH + O2
atropine N-oxide + NADP+ + H2O
show the reaction diagram
21% of the activity with monocrotaline
-
-
?
axillaridine + NADPH + H+ + O2
axillaridine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
axillaridine + NADPH + O2
axillaridine N-oxide + NADP+ + H2O
show the reaction diagram
axillarine + NADPH + H+ + O2
axillarine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
axillarine + NADPH + O2
axillarine N-oxide + NADP+ + H2O
show the reaction diagram
cysteamine + NADPH + H+ + O2
cysteamine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
heliotrine + NADPH + H+ + O2
heliotrine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
heliotrine + NADPH + O2
heliotrine N-oxide + NADP+ + H2O
show the reaction diagram
indicine + NADPH + H+ + O2
indicine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
indicine + NADPH + O2
indicine N-oxide + NADP+ + H2O
show the reaction diagram
lycopsamine + NADPH + O2
lycopsamine N-oxide + NADP+ + H2O
show the reaction diagram
monocrotaline + NADPH + H+ + O2
monocrotaline N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
monocrotaline + NADPH + O2
monocrotaline N-oxide + NADP+ + H2O
show the reaction diagram
nicotine + NADPH + H+ + O2
nicotine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
phalaenopsine + NADPH + H+ + O2
phalaenopsine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
phalaenopsine + NADPH + O2
phalaenopsine N-oxide + NADP+ + H2O
show the reaction diagram
19% of the activity with monocrotaline
-
-
?
retronecine + NADPH + H+ + O2
retronecine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
retrorsine + NADPH + H+ + O2
retrorsine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
retrorsine + NADPH + O2
retrorsine N-oxide + NADP+ + H2O
show the reaction diagram
rinderine + NADPH + H+ + O2
rinderine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
rinderine + NADPH + O2
rinderine N-oxide + NADP+ + H2O
show the reaction diagram
sarracine + NADPH + H+ + O2
sarracine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
senecionine + NADPH + H+ + O2
senecionine N-oxide + NADP+ + H2O
show the reaction diagram
senecionine + NADPH + O2
senecionine N-oxide + NADP+ + H2O
show the reaction diagram
seneciphylline + NADPH + H+ + O2
seneciphylline N-oxide + NADP+ + H2O
show the reaction diagram
-
second best substrate
-
-
?
seneciphylline + NADPH + O2
seneciphylline N-oxide + NADP+ + H2O
show the reaction diagram
senecivernine + NADPH + H+ + O2
senecivernine N-oxide + NADP+ + H2O
show the reaction diagram
-
-
-
-
?
senecivernine + NADPH + O2
senecivernine N-oxide + NADP+ + H2O
show the reaction diagram
triangularine + NADPH + O2
triangularine N-oxide + NADP+ + H2O
show the reaction diagram
-
60% of the activity with senecionine
-
?
additional information
?
-