1.14.12.25: p-cumate 2,3-dioxygenase
This is an abbreviated version!
For detailed information about p-cumate 2,3-dioxygenase, go to the full flat file.
Reaction
Synonyms
CmtAa, CmtAb, CmtAc, CmtAd, p-cumate dioxygenase
ECTree
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Substrates Products
Substrates Products on EC 1.14.12.25 - p-cumate 2,3-dioxygenase
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REACTION DIAGRAM
indole-2-carboxylate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-1H-indole-2-carboxylic acid + NAD+
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product rearranges spontaneously forming indigo, indirubin, and isatin
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indole-3-carboxylate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-1H-indole-3-carboxylic acid + NAD+
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m-toluate + NADH + H+ + O2
1,6-dihydroxy-5-methylcyclohexa-2,4-diene-1-carboxylic acid + NAD+
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p-cumate + NADH + H+ + O2
(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
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2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
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p-cumate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
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the substrate for the ring cleavage of 2,3-dihydroxy-p-cumate is formed from p-cumate in two reactions via a dihydrodiol intermediate (2,3-dihydroxy-4-isopropylcyclohexa-4,6-dienoate). Both hydroxyl atoms of the dihydrodiol are derived from the same molecule of 02
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