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1.14.12.25: p-cumate 2,3-dioxygenase

This is an abbreviated version!
For detailed information about p-cumate 2,3-dioxygenase, go to the full flat file.

Reaction

p-cumate
+
NADH
+
H+
+
O2
=
(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate
+
NAD+

Synonyms

CmtAa, CmtAb, CmtAc, CmtAd, p-cumate dioxygenase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.25 p-cumate 2,3-dioxygenase

Substrates Products

Substrates Products on EC 1.14.12.25 - p-cumate 2,3-dioxygenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
indole-2-carboxylate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-1H-indole-2-carboxylic acid + NAD+
show the reaction diagram
-
product rearranges spontaneously forming indigo, indirubin, and isatin
-
-
?
indole-3-carboxylate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-1H-indole-3-carboxylic acid + NAD+
show the reaction diagram
-
-
-
-
?
m-toluate + NADH + H+ + O2
1,6-dihydroxy-5-methylcyclohexa-2,4-diene-1-carboxylic acid + NAD+
show the reaction diagram
-
-
-
-
?
p-cumate + NADH + H+ + O2
(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
show the reaction diagram
-
-
-
-
?
p-cumate + NADH + H+ + O2
2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+
show the reaction diagram