Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.14.12.17: nitric oxide dioxygenase

This is an abbreviated version!
For detailed information about nitric oxide dioxygenase, go to the full flat file.

Word Map on EC 1.14.12.17

Reaction

2 nitric oxide + 2 O2 +

NAD(P)H
= 2 nitrate +
NAD(P)+
+
H+

Synonyms

barley hemoglobin, Cygb, cytoglobin, FHb1, flavoHb, flavohemoglobin, HbN, hemoglobin N, nitric oxide dioxygenase, nitric-oxide dioxygenase, NO degrading dioxygenase, NO dioxygenase, NOD, SHP, sphaeroides haem protein, type I flavohemoglobin, VHb, Vitreoscilla hemoglobin

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
                1.14.12.17 nitric oxide dioxygenase

General Information

General Information on EC 1.14.12.17 - nitric oxide dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
heterologous expression within a lentiviral delivery system results in markedly increased NADPH consumption, which is dependent on the addition of exogenous NO. Expression does not exhibit any noticeable toxicity or growth suppression in several tested mammalian cell types. Flavohemoglobin metabolizes endogenously synthesized NO to NO3- in mammalian cells without affecting NO synthesis itself
additional information
-
the enzyme is distinct from the microsomal NOD activity