1.14.12.1: anthranilate 1,2-dioxygenase (deaminating, decarboxylating)

This is an abbreviated version!
For detailed information about anthranilate 1,2-dioxygenase (deaminating, decarboxylating), go to the full flat file.

Reaction

Synonyms

AntDO, anthranilate hydroxylase, anthranilic acid hydroxylase, anthranilic hydroxylase, two-component anthranilate 1,2-dioxygenase

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

                1.14.12.1 anthranilate 1,2-dioxygenase (deaminating, decarboxylating)

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Results	in table
1265	AA Sequence
1	CAS Registry Number
6	Cloned(Commentary)
12	Cofactor
2	Inhibitors
1	KM Value [mM]
1	Metals/Ions
8	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
49	Organism
5	Pathway
1	pH Optimum
1	pH Range
6	Protein Variants
3	Purification (Commentary)
1	Reaction
5	Reaction Type
22	Reference
35	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 1.14.12.1 - anthranilate 1,2-dioxygenase (deaminating, decarboxylating)

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2,3-dihydroxybenzoic acid + NAD(P)H + O2 + H2O

?

Pseudomonas fluorescens

-

-

439106

-

-

?

anthranilate + NADPH + H+ + O2

catechol + CO2 + NADP+ + NH3

Pseudomonas aeruginosa

-

-

743231

-

-

?

anthranilic acid + alanine + O2

?

2 entries

anthranilic acid + alanine + O2

catechol + CO2 + NH3 + ?

2 entries

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

19 entries

anthranilic acid + NADH + O2 + H2O

catechol + CO2 + NAD+ + NH3

2 entries

benzoate + NAD(P)H + O2 + H2O

benzoate dihydrodiol + ?

2 entries

catechol + O2 + NAD(P)H + H2O

?

Pseudomonas fluorescens

-

-

439106

-

-

?

protocatechuic acid + NAD(P)H + O2 + H2O

?

Pseudomonas fluorescens

-

-

439106

-

-

?

salicylic acid + NAD(P)H + O2 + H2O

?

Burkholderia cepacia

Q84BZ2, Q84BZ3

-

659034

-

-

?

additional information

?

-

Pseudomonas fluorescens

-

salicylic acid and o-aminophenol are no substrates

439106

-

-

?

anthranilic acid + alanine + O2

?

Burkholderia cepacia

Q84BZ2, Q84BZ3

-

659034

-

-

?

anthranilic acid + alanine + O2

?

Burkholderia cepacia DBO1 / ATCC 29424

Q84BZ2, Q84BZ3

-

659034

-

-

?

anthranilic acid + alanine + O2

catechol + CO2 + NH3 + ?

Burkholderia cepacia

Q84BZ2, Q84BZ3

involved in the tryptophan degradation pathway

659034

-

-

?

anthranilic acid + alanine + O2

catechol + CO2 + NH3 + ?

Burkholderia cepacia DBO1 / ATCC 29424

Q84BZ2, Q84BZ3

involved in the tryptophan degradation pathway

659034

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Acinetobacter calcoaceticus

-

-

439108

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Acinetobacter sp.

-

-

396140, 439112

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Acinetobacter sp.

-

initial step in aerobic degradation of aromatic compounds, enables growth on anthranilate as sole carbon source

657969

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Acinetobacter sp. ADP1

-

-

396140

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Acinetobacter sp. ADP1

-

initial step in aerobic degradation of aromatic compounds, enables growth on anthranilate as sole carbon source

657969

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Acinetobacter sp. ADP1

-

-

439112

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Burkholderia cepacia

Q84BZ2, Q84BZ3

-

659034

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Burkholderia cepacia

Q84BZ2, Q84BZ3

involved in the tryptophan degradation pathway

659034

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Burkholderia cepacia DBO1 / ATCC 29424

Q84BZ2, Q84BZ3

-

659034

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Burkholderia cepacia DBO1 / ATCC 29424

Q84BZ2, Q84BZ3

involved in the tryptophan degradation pathway

659034

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Cutaneotrichosporon cutaneum

-

-

439110

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas aeruginosa

-

-

439107

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas chlororaphis subsp. aureofaciens

-

-

439109

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas fluorescens

-

-

439106

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas resinovorans

-

-

659053

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas resinovorans

-

initial step in aerobic degradation of aromatic compounds

659053

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas resinovorans CA10

-

-

659053

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas resinovorans CA10

-

initial step in aerobic degradation of aromatic compounds

659053

-

-

?

anthranilic acid + NAD(P)H + O2 + H2O

catechol + CO2 + NAD(P)+ + NH3

Pseudomonas sp.

-

-

396140, 439112

-

-

?

anthranilic acid + NADH + O2 + H2O

catechol + CO2 + NAD+ + NH3

Acinetobacter sp.

-

-

657969

-

-

?

anthranilic acid + NADH + O2 + H2O

catechol + CO2 + NAD+ + NH3

Acinetobacter sp. ADP1

-

-

657969

-

-

?

benzoate + NAD(P)H + O2 + H2O

benzoate dihydrodiol + ?

Burkholderia cepacia

Q84BZ2, Q84BZ3

poor substrate

659034

-

-

?

benzoate + NAD(P)H + O2 + H2O

benzoate dihydrodiol + ?

Burkholderia cepacia DBO1 / ATCC 29424

Q84BZ2, Q84BZ3

poor substrate

659034

-

-

?