1.14.11.7: procollagen-proline 3-dioxygenase

This is an abbreviated version!
For detailed information about procollagen-proline 3-dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.7

1.14.11.7

hypoxia-inducible

fibrosis

hydroxyproline

factor-1

endothelial

hydroxylases

hif-1alpha

erythropoietin

anemia

domain-containing

lysyl

ascorbate

oxygen-dependent

normoxic

hippel-lindau

4-hydroxylase

imperfecta

osteogenesis

dmog

dimethyloxalylglycine

bleomycin

factor-1alpha

oxygen-sensing

angiogenic

2-oxoglutarate-dependent

hypoxia-responsive

chick-embryo

hif-dependent

hydroxylysine

hif-prolyl

roxadustat

o2-dependent

bleomycin-induced

ppib

polycythemia

fkbp10

intratracheal

3-hydroxylation

3,4-dihydroxybenzoic

prolyl-hydroxylase

hepcidin

oxygen-sensitive

1.14.11.2

hydroxyproline-rich

col1a2

serpinh1

lindau

l-mimosine

erythropoiesis-stimulating

Reaction

Synonyms

LEPRE1, Leprel1, Leprel2, More, oxygenase, protocollagen proline 3-di-, P3H1, P3H2, P3H3, PHD3, proline,2-oxoglutarate 3-dioxygenase, prolyl 3-hydroxylase, prolyl 3-hydroxylase 1, prolyl 3-hydroxylase 2, prolyl 3-hydroxylase-2, prolyl hydroxylase, prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating, protocollagen proline 3-hydroxylase

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.7 procollagen-proline 3-dioxygenase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
3	Activating Compound
2848	AA Sequence
1	CAS Registry Number
5	Cloned(Commentary)
5	Cofactor
1112	Disease/ Diagnostics
5	Expression
24	General Information
1	General Stability
33	Inhibitors
26	Ki Value [mM]
8	KM Value [mM]
3	Localization
6	Metals/Ions
2	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
28	Organism
1	Pathway
1	pH Optimum
2	Posttranslational Modification
11	Protein Variants
6	Purification (Commentary)
1	Reaction
3	Reaction Type
27	Reference
45	Source Tissue
3	Specific Activity [micromol/min/mg]
30	Substrates and Products (Substrate)
51	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 1.14.11.7 - procollagen-proline 3-dioxygenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Systematic Name Search

[procollagen]-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)

Requires Fe2+ and ascorbate. The enzyme forms a complex with protein disulfide isomerase, and is located in the endoplasmic reticulum. It modifies proline residues within the procollagen peptide of certain collagen types. The modification is essential for proper collagen triple helix formation.