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1.14.11.6: thymine dioxygenase

This is an abbreviated version!
For detailed information about thymine dioxygenase, go to the full flat file.

Word Map on EC 1.14.11.6

Reaction

thymine
+
2-oxoglutarate
+
O2
=
5-Hydroxymethyluracil
+
succinate
+
CO2

Synonyms

5-hydroxy-methyluracil dioxygenase, 5-hydroxy-methyluracil oxygenase, EC 1.14.11.5, Fe2+/2-oxoglutarate dependent hydroxylase, J binding protein 1, J binding protein 2, J-binding protein 1, J-binding protein 2, JBP1, JBP2, More, T7H, thymidine hydroxylase, thymine 7-hydroxylase, thymine dioxygenase, thymine hydroxylase, thymine-7-hydroxylase

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.6 thymine dioxygenase

Inhibitors

Inhibitors on EC 1.14.11.6 - thymine dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-ethylthymine
-
70% inhibition at 5 mM with thymine as substrate
1-ethyluracil
-
60% inhibition at 5 mM with thymine as substrate
1-methylthymine
-
73% inhibition at 5 mM with thymine as substrate
1-Methyluracil
-
80% inhibition at 5 mM with thymine as substrate
2,4-dimethoxy-5-methylpyrimidine
-
68% inhibition at 5 mM with thymine as substrate
5,6-Dihydrothymine
-
73% inhibition at 5 mM with thymine as substrate
5-acetyluracil
-
poor competitive inhibitor
5-Aminouracil
-
100% inhibition at 5 mM with thymine as substrate
5-Bromouracil
-
95% inhibition at 5 mM with thymine as substrate
5-Carboxyuracil
-
-
5-Ethynyluracil
5-fluorouracil
-
linear non-competitive inhibitor
5-Formyluracil
5-Hydroxymethyluracil
-
competitive inhibitor against thymine, noncompetitive against oxygen
5-Hydroxyuracil
-
92% inhibition at 5 mM with thymine as substrate
5-Mercaptouracil
-
60% inhibition at 5 mM with thymine as substrate
5-methylaminouracil
-
100% inhibition at 5 mM with thymine as substrate
5-Nitrouracil
-
70% inhibition at 5 mM with thymine as substrate
6-Azathymine
-
94% inhibition at 5 mM with thymine as substrate
6-methylthymine
-
41% inhibition at 5 mM with thymine as substrate
6-Methyluracil
-
18% inhibition at 5 mM with thymine as substrate
Ni2+
binding structure with truncated enzyme mutant
Uracil