1.14.11.56: L-proline cis-4-hydroxylase
This is an abbreviated version!
For detailed information about L-proline cis-4-hydroxylase, go to the full flat file.
Word Map on EC 1.14.11.56
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1.14.11.56
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cis-4-hydroxy-l-proline
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sinorhizobium
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meliloti
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dioxygenase
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hydroxylases
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regioselectivity
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loti
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chop
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non-heme
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mesorhizobium
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synthesis
- 1.14.11.56
- cis-4-hydroxy-l-proline
-
sinorhizobium
- meliloti
- dioxygenase
- hydroxylases
-
regioselectivity
- loti
-
chop
-
non-heme
-
mesorhizobium
- synthesis
Reaction
Synonyms
cis-P4H, L-proline cis-4-hydroxylase, MlP4H, mlr6283, R03107, SmP4H
ECTree
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Metals Ions
Metals Ions on EC 1.14.11.56 - L-proline cis-4-hydroxylase
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Co2+
exogenous Co2+ is coordinated by residues H106, H154, and D108. Co2+ is a mimic of the catalytic metal center because of its stability under aerobic conditions and its enzymatic inactivity under anaerobic conditions. The cis-face of the C4 carbon of L-Pro is properly oriented toward Co2+, which in nature exists as FeIV=O during the hydroxylation reaction, to generate the enantiopure cis-4-hydroxyproline
Fe2+
Iron