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1.14.11.54: mRNA N1-methyladenine demethylase

This is an abbreviated version!
For detailed information about mRNA N1-methyladenine demethylase, go to the full flat file.

Word Map on EC 1.14.11.54

Reaction

N1-methyladenine in mRNA
+
2-oxoglutarate
+
O2
=
adenine in mRNA
+
formaldehyde
+
succinate
+
CO2

Synonyms

ABH3, AlkB, AlkB homolog 3, ALKBH3, alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, PCA-1, prostate cancer antigen-1

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.54 mRNA N1-methyladenine demethylase

Reference

Reference on EC 1.14.11.54 - mRNA N1-methyladenine demethylase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
You, C.; Wang, P.; Nay, S.L.; Wang, J.; Dai, X.; OConnor, T.R.; Wang, Y.
Roles of Aag, Alkbh2, and Alkbh3 in the repair of carboxymethylated and ethylated thymidine lesions
ACS Chem. Biol.
11
1332-1338
2016
Mus musculus (Q8K1E6)
Manually annotated by BRENDA team
Tasaki, M.; Shimada, K.; Kimura, H.; Tsujikawa, K.; Konishi, N.
ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer
Br. J. Cancer
104
700-706
2011
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Sundheim, O.; Vagbo, C.; Bjoras, M.; Sousa, M.; Talstad, V.; Aas, P.; Drablos, F.; Krokan, H.; Tainer, J.; Slupphaug, G.
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage
EMBO J.
25
3389-3397
2006
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Liefke, R.; Windhof-Jaidhauser, I.M.; Gaedcke, J.; Salinas-Riester, G.; Wu, F.; Ghadimi, M.; Dango, S.
The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells
Genome Med.
7
66
2015
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Dango, S.; Mosammaparast, N.; Sowa, M.E.; Xiong, L.J.; Wu, F.; Park, K.; Rubin, M.; Gygi, S.; Harper, J.W.; Shi, Y.
DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation
Mol. Cell
44
373-384
2011
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Li, X.; Xiong, X.; Wang, K.; Wang, L.; Shu, X.; Ma, S.; Yi, C.
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome
Nat. Chem. Biol.
12
311-316
2016
Homo sapiens
Manually annotated by BRENDA team
Zhu, C.; Yi, C.
Switching demethylation activities between AlkB family RNA/DNA demethylases through exchange of active-site residues
Angew. Chem. Int. Ed. Engl.
53
3659-3662
2014
Escherichia coli (P05050)
Manually annotated by BRENDA team
Ueda, Y.; Kitae, K.; Ooshio, I.; Fusamae, Y.; Kawaguchi, M.; Jingushi, K.; Harada, K.; Hirata, K.; Tsujikawa, K.
A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3
Biochem. Biophys. Rep.
5
476-481
2016
Homo sapiens (Q96Q83), Homo sapiens
Manually annotated by BRENDA team
Beharry, A.A.; Lacoste, S.; OConnor, T.R.; Kool, E.T.
Fluorescence monitoring of the oxidative repair of DNA alkylation damage by ALKBH3, a prostate cancer marker
J. Am. Chem. Soc.
138
3647-3650
2016
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Woo, H.H.; Chambers, S.K.
Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells
Biochim. Biophys. Acta Gene Regul. Mech.
1862
35-46
2019
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Esteve-Puig, R.; Climent, F.; Pineyro, D.; Domingo-Domenech, E.; Davalos, V.; Encuentra, M.; Rea, A.; Espejo-Herrera, N.; Soler, M.; Lopez, M.; Ortiz-Barahona, V.; Tapia, G.; Navarro, J.; Cid, J.; Farre, L.; Villanueva, A.; Casanova, I.; Mangues, R.
Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome
Blood
137
994-999
2021
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Chen, Z.; Qi, M.; Shen, B.; Luo, G.; Wu, Y.; Li, J.; Lu, Z.; Zheng, Z.; Dai, Q.; Wang, H.
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs
Nucleic Acids Res.
47
2533-2545
2019
Homo sapiens (Q96Q83)
Manually annotated by BRENDA team
Ueda, Y.; Ooshio, I.; Fusamae, Y.; Kitae, K.; Kawaguchi, M.; Jingushi, K.; Hase, H.; Harada, K.; Hirata, K.; Tsujikawa, K.
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
Sci. Rep.
7
42271
2017
Bombyx mori
Manually annotated by BRENDA team