1.14.11.48: xanthine dioxygenase
This is an abbreviated version!
For detailed information about xanthine dioxygenase, go to the full flat file.
Reaction
Synonyms
alpha-ketoglutarate-dependent xanthine hydroxylase, AO090001000152, TauD domain-containing protein, XanA, xanthine/alpha-ketoglutarate dioxygenase
ECTree
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Substrates Products
Substrates Products on EC 1.14.11.48 - xanthine dioxygenase
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REACTION DIAGRAM
additional information
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no activity with pyruvate, 2-oxobutyrate, phenyl pyruvate, and 4-hydroxyphenyl pyruvate
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urate + succinate + CO2
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xanthine + 2-oxoglutarate + O2
urate + succinate + CO2
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the enzyme is highly specific for xanthine. On the basis of the spectroscopic assay using standard conditions with 12 nM enzyme, no activity is detected when the enzyme is assayed with 0.08, 0.1, or 0.2 mM hypoxanthine, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, 9-methylxanthine, purine, 6-methylpurine, 2-hydroxypurine, 8-hydroxypurine, 2,8-dihydroxypurine, 2-hydroxy-6-methylpurine, allopurinol, allantoin, or adenosine diphosphate
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xanthine + 2-oxoglutarate + O2
urate + succinate + CO2
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