1.14.11.48: xanthine dioxygenase
This is an abbreviated version!
For detailed information about xanthine dioxygenase, go to the full flat file.
Reaction
Synonyms
alpha-ketoglutarate-dependent xanthine hydroxylase, AO090001000152, TauD domain-containing protein, XanA, xanthine/alpha-ketoglutarate dioxygenase
ECTree
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Substrates Products on EC 1.14.11.48 - xanthine dioxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
no activity with pyruvate, 2-oxobutyrate, phenyl pyruvate, and 4-hydroxyphenyl pyruvate
-
-
?
xanthine + 2-oxoglutarate + O2
urate + succinate + CO2
-
-
-
?
xanthine + 2-oxoglutarate + O2
urate + succinate + CO2
-
the enzyme is highly specific for xanthine. On the basis of the spectroscopic assay using standard conditions with 12 nM enzyme, no activity is detected when the enzyme is assayed with 0.08, 0.1, or 0.2 mM hypoxanthine, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, 9-methylxanthine, purine, 6-methylpurine, 2-hydroxypurine, 8-hydroxypurine, 2,8-dihydroxypurine, 2-hydroxy-6-methylpurine, allopurinol, allantoin, or adenosine diphosphate
-
-
?
xanthine + 2-oxoglutarate + O2
urate + succinate + CO2
-
-
-
?
