1.14.11.33: DNA oxidative demethylase

This is an abbreviated version, for detailed information about DNA oxidative demethylase, go to the full flat file.

Reaction

DNA-base-CH3
+
2-oxoglutarate
+
O2
=
DNA-base
+
formaldehyde
+
succinate
+
CO2

Synonyms

1-methyladenine-DNA dioxygenase, ABH1, ABH2, ABH3, AlkB, AlkB homolog 1, ALKBH2, ALKBH3, ALKBH8, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, FTO

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.33 DNA oxidative demethylase