1.14.11.28: proline 3-hydroxylase

This is an abbreviated version!
For detailed information about proline 3-hydroxylase, go to the full flat file.

Word Map on EC 1.14.11.28

1.14.11.28

2-oxoglutarate-dependent

leprel1

early-onset

ferrous

myopia

exome

autosomal-recessive

choroid

neovascularization

3-hydroxyproline

regio

pharmacology

4-hydroxylase

cataract

Reaction

Synonyms

C-P3H, C-P4H, collagen prolyl hydroxylases 3, collagen prolyl hydroxylases 4, L-proline-3-hydroxylase, Leprel1, Leprel2, P-3-H, P3H, P3H1, P3H2, P3H3, proline 3-hydroxylase, proline 3-hydroxylase type I, proline 3-hydroxylase type II, prolyl 3-hydrolase, prolyl 3-hydroxylase 2

ECTree

1 Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

1.14.11.28 proline 3-hydroxylase

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Results	in table
1	Activating Compound
11	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
5	Cofactor
1	Crystallization (Commentary)
4	Disease/ Diagnostics
4	Expression
2	General Information
14	Inhibitors
12	KM Value [mM]
1	Localization
7	Metals/Ions
5	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
51	Organism
3	pH Optimum
2	pH Stability
3	pI Value
1	Protein Variants
5	Purification (Commentary)
1	Reaction
21	Reference
12	Source Tissue
7	Specific Activity [micromol/min/mg]
30	Substrates and Products (Substrate)
4	Subunits
33	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.14.11.28 - proline 3-hydroxylase

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Citric acid

Streptomyces sp.

30% inhibition at 5 mM

665361

Co2+

2 entries

CoCl2

Streptomyces sp.

82% inhibition at 0.1 mM, 98% inhibition at 1 mM, 5 mM 2-oxoglutarate, 1 mM ferrous sulfate, 5 mM L-ascorbic acid, 100 mM TES pH 7.5, 30°C

663681

Cu2+

2 entries

CuSO4

Streptomyces sp.

59% inhibition at 0.1 mM, complete inhibition at 1 mM, 5 mM 2-oxoglutarate, 1 mM ferrous sulfate, 5 mM L-ascorbic acid, 100 mM TES pH 7.5, 30°C

663681

EDTA

3 entries

Ni2+

Streptomyces sp.

more than 50% inhibition at 1 mM

664403

Zn2+

2 entries

ZnSO4

Streptomyces sp.

95% inhibition at 0.1 mM, complete inhibition at 1 mM, 5 mM 2-oxoglutarate, 1 mM ferrous sulfate, 5 mM L-ascorbic acid, 100 mM TES pH 7.5, 30°C

663681