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1.14.11.21: clavaminate synthase

This is an abbreviated version!
For detailed information about clavaminate synthase, go to the full flat file.

Word Map on EC 1.14.11.21

Reaction

deoxyamidinoproclavaminate
+
2-oxoglutarate
+
O2
=
amidinoproclavaminate
+
succinate
+
CO2

Synonyms

CAS, CAS1, CAS2, clavaminate synthase 1, clavaminate synthase 2, clavaminic acid synthase, CS, synthase, clavaminate

ECTree

     1 Oxidoreductases
         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
                1.14.11.21 clavaminate synthase

Systematic Name

Systematic Name on EC 1.14.11.21 - clavaminate synthase

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SYSTEMATIC NAME
IUBMB Comments
deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Contains nonheme iron. Catalyses three separate oxidative reactions in the pathway for the biosythesis of the beta-lactamase inhibitor clavulanate in Streptomyces clavuligerus. The first step (hydroxylation) is separated from the latter two (oxidative cyclization and desaturation) by the action of EC 3.5.3.22, proclavaminate amidinohydrolase. The three reactions are all catalysed at the same nonheme iron site.