1.14.11.15: gibberellin 3beta-dioxygenase

This is an abbreviated version!
For detailed information about gibberellin 3beta-dioxygenase, go to the full flat file.

Reaction

Synonyms

(giberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating), AtGA3ox1, CYP115, DWARF1 D1 protein, DWF1, GA 3-oxidase, GA 3-oxidase 2, GA 3beta-hydroxylase, GA 3ox, GA3 oxidase, GA3 oxidase 1, GA3-oxidase, GA3-oxidase 1, GA3ox, GA3ox1, GA3OX4, gibberellin 3 oxidase, gibberellin 3 oxidase 1, gibberellin 3-beta-dioxygenase 1, gibberellin 3-beta-dioxygenase 2-1, gibberellin 3-beta-dioxygenase 2-2, gibberellin 3-beta-dioxygenase 2-3, gibberellin 3-oxidase, gibberellin 3-oxidase 1, gibberellin 3-oxidase 2, gibberellin 3beta dioxygenase, gibberellin 3beta-hydroxylase, MtGA3ox1, OsGA3ox1, oxygenase, gibberellin 3beta-di-, SbGA3ox2, SSL, TfGA3ox1, ZmGA3ox2

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor

                1.14.11.15 gibberellin 3beta-dioxygenase

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Results	in table
6	Activating Compound
120	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
1	Cofactor
1	Crystallization (Commentary)
2	Expression
40	General Information
48	Inhibitors
9	KM Value [mM]
4	Localization
6	Metals/Ions
3	Molecular Weight [Da]
49	Natural Substrates/ Products (Substrates)
75	Organism
4	Pathway
1	PDB ID
4	pH Optimum
2	pH Range
1	pH Stability
4	Protein Variants
9	Purification (Commentary)
1	Reaction
3	Reaction Type
64	Reference
38	Source Tissue
4	Specific Activity [micromol/min/mg]
111	Substrates and Products (Substrate)
2	Subunits
176	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Engineering

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Engineering on EC 1.14.11.15 - gibberellin 3beta-dioxygenase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

G126D

Medicago sativa

A9P5X4

amino acid change responsible for dwarf phenotype. Exogenously added gibberellic acid restores normal growth

689516

additional information

3 entries

additional information

Arabidopsis thaliana

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transgenic plant lines with green fluorescence protein-anti gibberellin24 antibody fusion construct (GFP-scFv), called A24-1, 2, and 3, up-regulation in the transgenic plant line A24-2 enhances biosynthesis of gibberellin 24 which accumulates compared to wild-type. GFP-scFv reduces rosette leaf development, delays flower induction, reduces stem elongation of main culm, especially in the early stage of inflorescence growth, later stem elongation of the main culm and lateral shoot elongation is much less affected

700861

additional information

Arabidopsis thaliana

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transgenic plants overexpressing an active NTL8 form and T-DNA insertional ntl8-1 mutant, under standard conditions, germinate with the same rate, under high salinity stress (150 mM NaCl) the germination of the NTL8 overexpressing mutant is considerably reduced while the NTL8-deficient mutant is less sensitive, independent of absiasic acid (ABA), NTL8-deficient mutant is not impaired by gibberellin biosynthetic inhibitor paclabutrazol (PAC), gibberellin downregulates NTL8 lowering its threshold for germination

700749

additional information

Nicotiana tabacum

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overexpression of isoform GA3ox1 in Nicotiana tabacum induces slight variations in phenotype and active gibberelin GA1 levels, concomitantly with an increase in gibberellin GA8 levels and a conspicuous induction of gibberellin 2-oxidases. The enzyme is negatively feedback regulated by high gibberellin levels

689507