1.14.11.1: gamma-butyrobetaine dioxygenase
This is an abbreviated version!
For detailed information about gamma-butyrobetaine dioxygenase, go to the full flat file.
Word Map on EC 1.14.11.1
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1.14.11.1
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cardioprotective
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carnitine-dependent
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3-2,2,2-trimethylhydrazinium
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mildronate
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trimethyllysine
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mid1
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alpha4
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medicine
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d-carnitine
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dihydrate
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drug development
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molecular biology
- 1.14.11.1
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cardioprotective
-
carnitine-dependent
-
3-2,2,2-trimethylhydrazinium
- mildronate
- trimethyllysine
- mid1
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alpha4
- medicine
- d-carnitine
- dihydrate
- drug development
- molecular biology
Reaction
Synonyms
4-trimethylaminobutyric acid dioxygenase, alpha-butyrobetaine hydroxylase, BBD, BBH, BBOX, BBOX1, Bu hydroxylase, butyrobetaine hydroxylase, gamma butyrobetaine hydroxylase, gamma-BBD, gamma-BBH, gamma-buryrobetaine dioxygenase, gamma-butyrobetaine dioxygenase, gamma-butyrobetaine hydroxylase, gamma-butyrobetaine hydroxylase 1, GBB hydroxylase, GBBH, hBBOX, oxygenase, gamma-butyrobetaine di-, psBBOX
ECTree
1.14.11.1 gamma-butyrobetaine dioxygenaseAdvanced search results
results (
results (KM Value
KM Value on EC 1.14.11.1 - gamma-butyrobetaine dioxygenase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.16
4-(trimethylammonio)butanoic acid
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co-substrate: 2-oxoglutarate, pH 7.5, 25°C, NMR assay
0.04
4-Dimethylaminobutyric acid
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in 20mM potassium phosphate buffer (pH 7.4) containing 50 mM KCl, 3mM 2-oxoglutarate, 10 mM sodium ascorbate, 0.5 mM DTT, 0.5 mM ammonium iron sulfate, 2.5 mg/ml bovine serum albumin, 0.01% (w/v) Triton X-100 and 2 mM 6-N-trimethyllysine
0.02
(2S)-3-carboxy-N-(fluoromethyl)-2-hydroxy-N,N-dimethylpropan-1-aminium
pH 7.5, temperature not specified in the publication
0.412
(2S)-3-carboxy-N-(fluoromethyl)-2-hydroxy-N,N-dimethylpropan-1-aminium
pH 7.5, temperature not specified in the publication
0.02
(3R)-3-fluoro-4-(trimethylammonio)butanoate
pH 7.5, temperature not specified in the publication
0.623
(3R)-3-fluoro-4-(trimethylammonio)butanoate
pH 7.5, temperature not specified in the publication
0.012
(3S)-3-fluoro-4-(trimethylammonio)butanoate
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co-substrate: 2-oxoglutarate, pH 7.5, 25°C, NMR assay
0.083
(3S)-3-fluoro-4-(trimethylammonio)butanoate
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co-substrate: 2-oxoglutarate, pH 7.5, 25°C, fluoride assay
0.026
2-oxoglutarate
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co-substrate: 4-(trimethylammonio)butanoic acid, pH 7.5, 25°C, NMR assay
0.063
2-oxoglutarate
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in 20mM potassium phosphate buffer (pH 7.4) containing 50 mM KCl, 3mM 2-oxoglutarate, 10 mM sodium ascorbate, 0.5 mM DTT, 0.5 mM ammonium iron sulfate, 2.5 mg/ml bovine serum albumin, 0.01% (w/v) Triton X-100 and 2 mM 6-N-trimethyllysine
0.1 - 0.13
2-oxoglutarate
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gamma-butyrobetaine, values about the same for all three isozymes
0.15
2-oxoglutarate
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co-substrate: (3S)-3-fluoro-4-(trimethylammonio)butanoate, pH 7.5, 25°C, NMR assay
0.153
2-oxoglutarate
pH 7.5, temperature not specified in the publication
0.47
2-oxoglutarate
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co-substrate: (3S)-3-fluoro-4-(trimethylammonio)butanoate, pH 7.5, 25°C, fluoride assay
0.532
2-oxoglutarate
pH 7.5, temperature not specified in the publication
0.0042
4-Trimethylammoniobutanoate
pH 7.5, temperature not specified in the publication
0.013
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of 1-day-old domestic pig, pH 7.4, 37°C
0.025
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of 7-day-old domestic pig, pH 7.4, 37°C
0.026
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of 56-day-old domestic pig, pH 7.4, 37°C
0.032
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of 1-day-old domestic pig, pH 7.4, 37°C
0.037
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of 56-day-old domestic pig, pH 7.4, 37°C
0.038
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of 21-day-old domestic pig, pH 7.4, 37°C
0.041
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of 35-day-old domestic pig, pH 7.4, 37°C
0.053
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of newborn domestic pig, pH 7.4, 37°C
0.06
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in liver of 210-day-old domestic pig, pH 7.4, 37°C
0.061
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of 7-day-old domestic pig, pH 7.4, 37°C
0.063
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of 21-day-old domestic pig, pH 7.4, 37°C
0.074
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of 210-day-old domestic pig, pH 7.4, 37°C
0.086
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of 35-day-old domestic pig, pH 7.4, 37°C
0.119
4-Trimethylammoniobutanoate
apparent kinetic constant (Km), in kidney of newborn domestic pig, pH 7.4, 37°C
0.163
4-Trimethylammoniobutanoate
pH 7.5, temperature not specified in the publication, only the Michaelis-Menten range is fitted
2.474
4-Trimethylammoniobutanoate
pH 7.5, temperature not specified in the publication, the whole range is fitted
additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
kinetic analysis, overview
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