1.13.12.2: lysine 2-monooxygenase
This is an abbreviated version!
For detailed information about lysine 2-monooxygenase, go to the full flat file.
Word Map on EC 1.13.12.2
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1.13.12.2
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putida
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5-aminovalerate
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glutarate
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fed-batch
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nylon
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synthesis
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fluorescens
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semialdehyde
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1,5-pentanediol
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polyamides
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glutamicum
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flavoproteins
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corynebacterium
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l-pipecolate
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biotechnology
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4-aminobutyrate
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five-carbon
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amidohydrolase
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his6-tagged
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cadaverine
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biomass
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transaminase
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permease
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byproduct
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deamination
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putrescine
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bio-based
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feedstock
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codon-optimized
- 1.13.12.2
- putida
- 5-aminovalerate
- glutarate
-
fed-batch
-
nylon
- synthesis
- fluorescens
- semialdehyde
- 1,5-pentanediol
- polyamides
- glutamicum
- flavoproteins
-
corynebacterium
- l-pipecolate
- biotechnology
- 4-aminobutyrate
-
five-carbon
-
amidohydrolase
-
his6-tagged
- cadaverine
- biomass
- transaminase
-
permease
-
byproduct
-
deamination
- putrescine
-
bio-based
-
feedstock
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codon-optimized
Reaction
Synonyms
davB, L-AAO/MOG, L-amino acid oxidase/monooxygenase, L-LOX/MOG, L-lysine 2-monooxygenase, L-lysine monooxygenase, L-lysine oxidase/monooxygenase, L-lysine-2-monooxygenase, lysine monooxygenase, lysine oxygenase
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Application
Application on EC 1.13.12.2 - lysine 2-monooxygenase
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biotechnology
synthesis
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immobilization of L-lysine-2-monooxygenase on an electrode surface, via polymerization of polyvinyl alcohol, provides a biosensor that detects L-lysine concentrations down to 0.01 mM
biotechnology
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immobilization on silica gel provides a flow-through analyzer for concentrations between 5.5 and 55 mM L-lysine at pH 8.2, it retains 50% activity after two months
installation of an Escherichia coli whole-cell biocatalytic system, environmentally friendly, for industrial production of 5-aminovalerate using recombinant enzymes 5-aminovaleramide amidohydrolase and L-lysine 2-monooxygenase, overview
synthesis
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L-lysine is a potential feedstock for the production of bio-based precursors for engineering plastics. Usage of the enzyme in a microbial process for high-level conversion of L-lysine into 5-aminovalerate that can be used as a monomer in nylon 6,5 synthesis, method overview
synthesis
the enzyme can be used for production of 5-aminovalerate, a potential C5 platform chemical for synthesis of valerolactam, 5-hydroxyvalerate, glutarate, and 1,5-pentanediol. Escherichia coli is engineered for production of 5-aminovalerate from L-lysine by coupled reaction of recombinant DavB, L-lysine monooxygenase, and recombinant DavA, 5-aminovaleramidase. Because L-lysine is an industrial fermentation product, the two-enzyme coupled system presents a promising alternative for the production of 5-aminovalerate
synthesis
2-monooxygenase (DavB) and delta-aminovaleramidase (DavA) are co-expressed in Escherichia coli BL21(DE3) to produce nylon-5 monomer 5-aminovalerate from L-lysine. PP2911 (4-aminobutyrate transporter in Pseudomonas putida) and LysP (the lysine specific permease in Escherichia coli) are overexpressed to promote 5-aminovalerate production using whole cells of recombinant Escherichia coli. The constructed Escherichia coli strain overexpressing transport proteins exhibits good 5-aminovalerate production performance and might serve as a promising biocatalyst for 5-aminovalerate production from L-lysine. This strategy not only shows an efficient process for the production of nylon monomers but also might be used in production of other chemicals