1.13.12.16: nitronate monooxygenase
This is an abbreviated version!
For detailed information about nitronate monooxygenase, go to the full flat file.
Word Map on EC 1.13.12.16
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1.13.12.16
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nitroalkanes
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flavin
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nitroethane
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neurospora
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crassa
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fmn
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hansenula
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mrakii
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flavosemiquinone
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1-nitropropane
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denitrification
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3-nitropropionic
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ansochromogenes
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fmn-dependent
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saturnus
- 1.13.12.16
- nitroalkanes
- flavin
- nitroethane
- neurospora
- crassa
- fmn
- hansenula
- mrakii
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flavosemiquinone
- 1-nitropropane
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denitrification
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3-nitropropionic
- ansochromogenes
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fmn-dependent
- saturnus
Reaction
Synonyms
2-nitropropane dioxygenase, EC 1.13.11.32, NAO, ncd2, nitroalkane oxidase, nitroalkane-oxidizing enzyme, nitronate monooxygenase, nitropropane dioxygenase, NMO, NMO-Nc, NMO-Ws, nmoA, Npd1, Npd2, Npd3, Npd4, Npd5, Npd6, oxidase, nitroalkane, oxygenase, 2-nitropropane di-, P3N monooxygenase, Pa-NMO, PA4202, protein PA4202, Rv1894c, Sa-NAO
ECTree
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Inhibitors
Inhibitors on EC 1.13.12.16 - nitronate monooxygenase
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acetone
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inhibits competitively against 2-nitropropane, no inhibitory effect against O2
Butanal
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competitive inhibitor with respect to ethylnitronate as substrate
hexanal
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competitive inhibitor with respect to ethylnitronate as substrate
NADPH
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competitive inhibitor. oxygenation is inhibited approximately 100% by 0.1 mM NADPH, respectively, although NAD+ and NADP+ are ineffective even at 1 mM. During the inhibition, NADH and NADPH are oxidized
nitrite
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inhibits noncompetitively against 2-nitropropane, functioned as a noncompetitive inhibitor against oxygen in the presence of excess 2-nitropropane (50 mM)
pentanal
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competitive inhibitor with respect to ethylnitronate as substrate
propanal
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competitive inhibitor with respect to ethylnitronate as substrate
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competitive inhibitor. Oxygenation is inhibited approximately 86% by 0.1 mM NADH, although NAD+ and NADP+ are ineffective even at 1 mM. During the inhibition, NADH and NADPH are oxidized
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competitive inhibitor with respect to ethylnitronate as substrate
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competitive inhibitor with respect to ethylnitronate as substrate
Superoxide dismutase
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Cu and Zn-superoxide dismutase of bovine blood, Mn-superoxide dismutases of bacilli, Fe-superoxide dismutase of Serratia marcescens
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i.e. pyrocatechol-3,5-disulfonate disodium salt; i.e. pyrocatechol-3,5-disulfonate disodium salt, strong inhibition
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EDTA does not inhibit the enzyme significantly. Iodoacetate is almost ineffective
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additional information
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inhibition by superoxide dismutase and various scavengers for superoxide; phenol, tryptophan, and tryptamine show no effect on the reaction
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additional information
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not affected by hydroxyl radical scavengers such as mannitol
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additional information
superoxide dismutase and catalase have no effect on the enzymatic activity
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additional information
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superoxide dismutase and catalase have no effect on the enzymatic activity
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additional information
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8% (w/v) PEG 3350 shows no significant effect on the enzyme activity
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additional information
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no inhibition: tiron, superoxide dismutase, EDTA, cysteine, epinephrine, NADH, NADPH, and 2-mercaptoethanol
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additional information
no inhibition by valeric acid and EDTA
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