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1.13.12.13: Oplophorus-luciferin 2-monooxygenase

This is an abbreviated version!
For detailed information about Oplophorus-luciferin 2-monooxygenase, go to the full flat file.

Word Map on EC 1.13.12.13

Reaction

Oplophorus luciferin
+
O2
=
oxidized Oplophorus luciferin
 +
CO2
 +
hnu

Synonyms

19kOLase, CXXC-Oluc, imidazopyrazinone-type luciferase, KAZ, luciferase, nanoKAZ, NanoLuc, Oluc-19, Oplophorus luciferase

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)
                1.13.12.13 Oplophorus-luciferin 2-monooxygenase

Inhibitors

Inhibitors on EC 1.13.12.13 - Oplophorus-luciferin 2-monooxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,8-dibenzyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
2-[(5-ethylfuran-2-yl)methyl]-8-[(2-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
2-[(5-ethylfuran-2-yl)methyl]-8-[(3-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
2-[(5-methylfuran-2-yl)methyl]-8-[(3-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
6-(2-fluorophenyl)-8-[(4-fluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-2-[(2-fluorophenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-2-[(3-methylphenyl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-2-[(furan-2-yl)methyl]-6-(3-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-2-[[3-(furan-2-yl)phenyl]methyl]-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-6-(3-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-benzyl-6-(4-hydroxyphenyl)-2-[(5-methylfuran-2-yl)methyl]imidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-[(2,3-difluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-[(2-fluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-[(3,5-difluorophenyl)methyl]-2-[(5-methylfuran-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
8-[(3,5-difluorophenyl)methyl]-2-[(furan-2-yl)methyl]-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
Q9GV45; Q9GV46
-
-
coelenterazine
Q9GV45; Q9GV46
-
Cu2+
-
0.001 mM, 98% inhibition
h-coelenterazine
Q9GV45; Q9GV46
-
iodoacetamide
-
1 mM, catalytic subunit kOLase, 50% residual activity, native enzyme, 80% residual activity
N-ethylmaleimide
-
0.1 mM, catalytic subunit kOLase, 1% residual activity, native enzyme, 81% residual activity