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1.13.11.65: carotenoid isomerooxygenase

This is an abbreviated version!
For detailed information about carotenoid isomerooxygenase, go to the full flat file.

Word Map on EC 1.13.11.65

Reaction

zeaxanthin
+
O2
=
(3R)-11-cis-3-hydroxyretinal
+
(3R)-all-trans-3-hydroxyretinal

Synonyms

carotenoid cleavage oxygenase, CCO, CSO2, NinaB, ppsir_15490, Rv0654, sala_1698, SIR-1

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.65 carotenoid isomerooxygenase

Systematic Name

Systematic Name on EC 1.13.11.65 - carotenoid isomerooxygenase

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SYSTEMATIC NAME
IUBMB Comments
zeaxanthin:oxygen 15,15'-oxidoreductase (bond-cleaving, cis-isomerizing)
The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including beta-carotene, alpha-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule.