1.13.11.64: 5-nitrosalicylate dioxygenase
This is an abbreviated version!
For detailed information about 5-nitrosalicylate dioxygenase, go to the full flat file.
Reaction
Synonyms
5NSA dioxygenase, naaB
ECTree
1.13.11.64 5-nitrosalicylate dioxygenaseAdvanced search results
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Substrates Products on EC 1.13.11.64 - 5-nitrosalicylate dioxygenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-nitro-6-oxohepta-2,4-dienedioate
2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite
-
2nd step of reaction, spontaneous
-
?
5-chlorosalicylate + O2
2-oxo-3-(5-oxofuran-2-ylidene)propanoate + chloride
-
overall reaction
-
?
5-nitrosalicylate + O2
4-nitro-6-oxohepta-2,4-dienedioate
-
1st step of reaction
-
?
5-nitrosalicylate + O2
2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite
oxidation catalyzed by cell extracts requires 0.97 mol O2/mol 5-nitrosalicylate
overall reaction
-
?
5-nitrosalicylate + O2
2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite
results are consistent with a dioxygenase-catalyzed ring opening followed by spontaneous lactonization and nitrite elimination and enzyme-catalyzed hydrolysis of the lactone to produce maleylpyruvate
overall reaction. The initial ring fission product of 5-nitrosalicylate dioxygenation is spontaneously and rapidly cyclized to form lactones, accompanied by the release of NO2-
-
?
additional information
?
-
no substrates: 4-chlorocatechol, 4-nitrocatechol
-
-
?
additional information
?
-
-
no substrates: 4-chlorocatechol, 4-nitrocatechol
-
-
?
