1.13.11.63: beta-carotene 15,15'-dioxygenase
This is an abbreviated version!
For detailed information about beta-carotene 15,15'-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.63
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1.13.11.63
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beta-cyclodextrin
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cyclodextrins
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gamma-cds
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guest
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alpha-cd
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enantiomer
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selector
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host-guest
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dissolution
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enantioseparation
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gamma-cyclodextrins
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supramolecular
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racemic
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diagram
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voltage
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encapsulation
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surfactant
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electrolyte
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roesy
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micellar
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uv-vis
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infrared
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hydroxypropyl-beta-cyclodextrin
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electrokinetic
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enantioselectivity
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alpha-cyclodextrin
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spectrofluorimetric
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diagnostics
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adamantane
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knead
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synthesis
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glucanotransferase
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deltag
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permethylated
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fused-silica
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medicine
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adamantyl
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provitamin
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photophysical
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borate
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diffractometry
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cgtases
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overhauser
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hydroxypropylated
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photodegradation
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analysis
- 1.13.11.63
- beta-cyclodextrin
- cyclodextrins
-
gamma-cds
-
guest
-
alpha-cd
-
enantiomer
-
selector
-
host-guest
-
dissolution
-
enantioseparation
- gamma-cyclodextrins
-
supramolecular
-
racemic
-
diagram
-
voltage
-
encapsulation
- surfactant
-
electrolyte
-
roesy
-
micellar
-
uv-vis
-
infrared
- hydroxypropyl-beta-cyclodextrin
-
electrokinetic
-
enantioselectivity
- alpha-cyclodextrin
-
spectrofluorimetric
- diagnostics
- adamantane
-
knead
- synthesis
-
glucanotransferase
-
deltag
-
permethylated
-
fused-silica
- medicine
-
adamantyl
-
provitamin
-
photophysical
- borate
-
diffractometry
- cgtases
-
overhauser
-
hydroxypropylated
-
photodegradation
- analysis
Reaction
Synonyms
BC-15,15'-oxygenase, BCM, BCMO, Bcmo1, Bcmo2, BCO, BCO1, BCO2, Bcox, beta,beta-carotene 15,15'-mono-oxygenase 1, beta,beta-carotene 15,15'-monooxygenase, beta,beta-carotene 15,15'-monooxygenase 1, beta,beta-carotene 15,15'-monooxygenase-1, beta,beta-carotene 15,15-monooxygenase 1, beta,beta-carotene-15,15'-monooxygenase, beta,beta-carotene-15,15'-oxygenase, beta-carotene 15,15' oxygenase, beta-carotene 15,15'-dioxygenase, beta-carotene 15,15'-monooxygenase, beta-carotene 15,15'-monooxygenase 1, beta-carotene 15,15'-oxygenase, beta-carotene 15,15-monooxygenase, beta-carotene dioxygenase 1, beta-carotene oxygenase 2, beta-carotene-15,15'-dioxygenase, beta-carotene-15,15'-monooxygenase, beta-carotene-15,15'-oxygenase, beta-carotene-15,15'-oxygenase-1, beta-carotene-15,15'-oxygenase-2, beta-CD, betaCDIOX, betaCO, BLH, brp/blh-family beta-carotene monooxygenase, brpA, carotenoid oxygenase, Ci-BCO, CMO1, EC 1.13.11.21, EC 1.14.99.36, NinaB
ECTree
1.13.11.63 beta-carotene 15,15'-dioxygenaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 1.13.11.63 - beta-carotene 15,15'-dioxygenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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predominantly expressed in ocellus photoreceptor cells of the larva
additional information
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when TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence
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in epithelial cells of the mucosa, quantitative RT-PCR expression analysis, and in situ hybridization
mRNA is abundant at embryonic day 7, with lower expression at embryonic days 11, 13 and 15
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of several tissues including stomach, intestine, colon, prostate glands, and endometrium
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of several tissues including stomach, intestine, colon, prostate glands, and endometrium
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of several tissues including stomach, intestine, colon, prostate glands, and endometrium
beta-carotene-15,15'-dioxygenase (BCO1) protein is not expressed in adult hearts of male wild-type mice
highest expression in duodenum, mRNA level in ileum is markedly low
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activity detected in two subclones of Caco-2, PF11 and TC7. When TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence. No activity detected in IPEC-1, HepG2, HL60, Wurzburg, or parent Caco-2, PF11 and TC7
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activity is 20-30% greater in vitamin-A deficient animals than in the controls
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activity of enzyme in intestinal mucosa is higher after feeding with oleic acid or eicosapentanoic acid than with linoleic acid
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high expression, expression in small intestine is increased by vitamin A deficiency. Upregulation is suppressed by all-trans retinoic acid or 9-cis retinoic acid
immunohistochemistry shows strong BCO1 immunoreactivity in the duodenum, particularly in Brunner's glands
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diffuse distribution in the lobules, quantitative RT-PCR expression analysis and in situ hybridization
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high expression, expression is suppressed by all-trans retinoic acid
BCO1 is highly expressed in hepatocytes, mucosal epithelium, hepatic stellate cells, and portal endothelial cells in liver
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high expression, expression is increased by vitamin A deficiency. Upregulation is suppressed by all-trans retinoic acid or 9-cis retinoic acid
additional information
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enzyme activity is similar in the duodenum, but pigmented animals have higher enzyme activity in the liver, eevnthough not high enough to prevent the storage of beta-carotene in adipose tissues
additional information
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BCMO1 expression in the exocrine portion of the pancreas, epidermis of the skin, and ciliary body pigment epithelia and RPE of the eye
additional information
quantitative reverse-transcriptase PCR enzyme expression analysis
additional information
real-time quantitative RT-PCR enzyme expression analysis
additional information
retinoid levels in the developing liver and brain at mid-gestation, overview. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type
additional information
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BCMO1 expression in the exocrine portion of the pancreas, epidermis of the skin, and ciliary body pigment epithelia and RPE of the eye
additional information
cellular expression and localization of BCO1 and BCO2 proteins in rat liver and intestine, immunohistochemic analysis, overview. BCO1 shows diffuse presence along epithelia with strong immunoreactivity in endothelial cells and in certain epithelial cells, possible intestinal retinoid storage cells
additional information
quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls
additional information
quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls
additional information
tissue expression levels of the enzyme with and without dehydroepiandrosterone addition, overview
additional information
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quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls
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additional information
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tissue expression levels of the enzyme with and without dehydroepiandrosterone addition, overview
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additional information
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BCMO1 expression in the exocrine portion of the pancreas, epidermis of the skin, and ciliary body pigment epithelia and RPE of the eye
