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Lakshamanan, M.R.; Chansang, H.; Olson, J.A.
Purification and properties of carotene 15,15-dioxygenase of rabbit intestine
J. Lipid Res.
13
477-482
1972
Gallus gallus, Clarias batrachus, Oryctolagus cuniculus, Domania subtryug, no activity in Felis catus
brenda
Villard, L.; Bates, C.J.
Carotene dioxygenase (EC 1.13.11.21) activity in rat intestine: effects of vitamin A deficiency and of pregnancy
Br. J. Nutr.
56
115-122
1986
Rattus norvegicus
brenda
Lakshman, M.R.; Mychkovsky, I.; Attlesey, M.
Enzymatic conversion of all-trans-beta-carotene to retinal by a cytosolic enzyme from rabbit and rat intestinal mucosa
Proc. Natl. Acad. Sci. USA
86
9124-9128
1989
Oryctolagus cuniculus, Rattus norvegicus
brenda
Goodman, D.S.; Olson, J.A.
The conversion of all-trans beta-carotene into retinal
Methods Enzymol.
15
462-475
1969
Rattus norvegicus
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brenda
Goodman, D.S.; Huang, H.S.; Kanai, M.; Shiratori, T.
The enzymatic conversion of all-trans beta-carotene into retinal
J. Biol. Chem.
242
3543-3554
1967
Rattus norvegicus
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brenda
Lindqvist, A.; Andersson, S.
Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase
J. Biol. Chem.
277
23942-23948
2002
Homo sapiens (Q9HAY6), Homo sapiens
brenda
Wyss, A.; Wirtz, G.M.; Woggon, W.D.; Brugger, R.; Wyss, M.; Friedlein, A.; Riss, G.; Bachmann, H.; Hunziker, W.
Expression pattern and localization of beta,beta-carotene 15,15'-dioxygenase in different tissues
Biochem. J.
354
521-529
2001
Gallus gallus (Q9I993)
brenda
Redmond, T.M.; Gentleman, S.; Duncan, T.; Yu, S.; Wiggert, B.; Gantt, E.; Cunningham, F.X.
Identification, expression, and substrate specificity of a mammalian beta-carotene 15,15'-dioxygenase
J. Biol. Chem.
276
6560-6565
2001
Mus musculus (Q9JJS6), Mus musculus
brenda
During, A.; Albaugh, G.; Smith, J.C., Jr.
Characterization of beta-carotene 15,15'-dioxygenase activity in TC7 clone of human intestinal cell line Caco-2
Biochem. Biophys. Res. Commun.
249
467-474
1998
Homo sapiens
brenda
Devery, J.; Milborrow, B.V.
beta-Carotene-15,15'-dioxygenase (EC 1.13.11.21) isolation reaction mechanism and an improved assay procedure
Br. J. Nutr.
72
397-344
1994
Cavia porcellus, Gallus gallus, Sus scrofa
brenda
Grolier, P.; Duszka, C.; Borel, P.; Alexandre-Gouabau, M.C.; Azais-Braesco, V.
In vitro and in vivo inhibition of beta-carotene dioxygenase activity by canthaxanthin in rat intestine
Arch. Biochem. Biophys.
348
233-238
1997
Rattus norvegicus
brenda
Yan, W.; Jang, G.F.; Haeseleer, F.; Esumi, N.; Chang, J.; Kerrigan, M.; Campochiaro, M.; Campochiaro, P.; Palczewski, K.; Zack, D.J.
Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium
Genomics
72
193-202
2001
Homo sapiens (Q9HAY6)
brenda
Nagao, A.; Maeda, M.; Lim, B.P.; Kobayashi, H.; Terao, J.
Inhibition of beta-carotene-15,15'-dioxygenase activity by dietary flavonoids
J. Nutr. Biochem.
11
348-355
2000
Sus scrofa
brenda
During, A.; Smith, M.K.; Piper, J.B.; Smith, J.C.
beta-Carotene 15,15'-dioxygenase activity in human tissues and cells: evidence of an iron dependency
J. Nutr. Biochem.
12
640-647
2001
Homo sapiens
brenda
Ershov Yu, V.; Bykhovsky, V.; Dmitrovskii, A.A.
Stabilization and competitive inhibition of beta-carotene 15,15'-dioxygenase by carotenoids
Biochem. Mol. Biol. Int.
34
755-763
1994
Oryctolagus cuniculus
brenda
Yang, A.; Tume, R.K.
A comparison of beta-carotene-splitting activity isolated from intestinal mucosa of pasture-grazed sheep, goats and cattle
Biochem. Mol. Biol. Int.
30
209-217
1993
Bos taurus, Capra hircus, Ovis aries
brenda
During, A.; Fields, M.; Lewis, C.G.; Smith, J.C.
beta-Carotene 15,15'-dioxygenase activity is responsive to copper and iron concentrations in rat small intestine
J. Am. Coll. Nutr.
18
309-315
1999
Rattus norvegicus
brenda
Lampert, J.M.; Holzschuh, J.; Hessel, S.; Driever, W.; Vogt, K.; von Lintig, J.
Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis
Development
130
2173-2186
2003
Danio rerio (Q90WH4), Danio rerio
brenda
Takitani, K.; Zhu, C.L.; Inoue, A.; Tamai, H.
Molecular cloning of the rat beta-carotene 15,15-monooxygenase gene and its regulation by retinoic acid
Eur. J. Nutr.
45
320-326
2006
Rattus norvegicus
brenda
Poliakov, E.; Gentleman, S.; Cunningham, F.X.; Miller-Ihli, N.J.; Redmond, T.M.
Key role of conserved histidines in recombinant mouse beta-carotene 15,15-monooxygenase-1 activity
J. Biol. Chem.
280
29217-29223
2005
Mus musculus (Q9JJS6), Mus musculus
brenda
Raju, M.; Lakshminarayana, R.; Krishnakantha, T.P.; Baskaran, V.
Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the beta-carotene uptake and its cleavage into retinol in rats
Mol. Cell. Biochem.
288
7-15
2006
Rattus norvegicus
brenda
Takimoto, N.; Kusakabe, T.; Horie, T.; Miyamoto, Y.; Tsuda, M.
Origin of the vertebrate visual cycle: III. Distinct distribution of RPE65 and beta-carotene 15,15-monooxygenase homologues in Ciona intestinalis
Photochem. Photobiol.
82
1468-1474
2007
Ciona intestinalis
brenda
Fierce, Y.; de Morais Vieira, M.; Piantedosi, R.; Wyss, A.; Blaner, W.S.; Paik, J.
In vitro and in vivo characterization of retinoid synthesis from beta-carotene
Arch. Biochem. Biophys.
472
126-138
2008
Homo sapiens, Mus musculus
brenda
Morales, A.; Gonzalez, A.; Varela-Echavarria, A.; Shimada, A.; Mora, O.
Differences in expression and activity of beta,beta-carotene-15,15'-oxygenase in liver and duodenum of cattle with yellow or white fat
J. Anim. Physiol. Anim. Nutr. (Berl.)
91
341-346
2007
Bos taurus
brenda
Ferrucci, L.; Perry, J.R.; Matteini, A.; Perola, M.; Tanaka, T.; Silander, K.; Rice, N.; Melzer, D.; Murray, A.; Cluett, C.; Fried, L.P.; Albanes, D.; Corsi, A.M.; Cherubini, A.; Guralnik, J.; Bandinelli, S.; Singleton, A.; Virtamo, J.; Walston, J.; Semba, R.D.; Frayling, T.M.
Common variation in the beta-carotene 15,15-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study
Am. J. Hum. Genet.
84
123-133
2009
Homo sapiens (Q9HAY6), Homo sapiens
brenda
Takitani, K.; Matsumura, H.; Nakakura, H.; Ashida, A.; Tamai, H.
Expression of beta-carotene 15,15'-monooxygenase gene and retinol status in rats with puromycin aminonucleoside-induced nephrosis
Biofactors
33
293-300
2008
Rattus norvegicus
brenda
Takitani, K.; Miyazaki, H.; Takaya, R.; Tamai, H.
Expression of beta-carotene 15,15-monooxygenase gene and retinol status in type 2 diabetic Goto-Kakizaki rats
Biofactors
33
77-83
2008
Rattus norvegicus
brenda
Park, C.; Lee, S.; Kim, Y.; Kim, E.; Sin, H.; Oh, D.; Kim, S.; Um, S.
Utilization of the recombinant human beta-carotene-15,15-monooxygenase gene in Escherichia coli and mammalian cells
Biotechnol. Lett.
30
735-741
2008
Homo sapiens (Q9HAY6), Homo sapiens
brenda
Kim, Y.S.; Oh, D.K.
Substrate specificity of a recombinant chicken beta-carotene 15,15-monooxygenase that converts beta-carotene into retinal
Biotechnol. Lett.
31
403-408
2009
Gallus gallus (Q9I993), Gallus gallus
brenda
Kim, N.; Kim, Y.; Kim, H.; Oh, D.
Optimized formation of detergent micelles of beta-carotene and retinal production using recombinant human beta, beta-carotene 15,15-monooxygenase
Biotechnol. Prog.
24
227-231
2008
Homo sapiens (Q9HAY6), Homo sapiens
brenda
Seino, Y.; Miki, T.; Kiyonari, H.; Abe, T.; Fujimoto, W.; Kimura, K.; Takeuchi, A.; Takahashi, Y.; Oiso, Y.; Iwanaga, T.; Seino, S.
Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression
J. Biol. Chem.
283
4905-4911
2008
Mus musculus (Q9JJS6)
brenda
Oberhauser, V.; Voolstra, O.; Bangert, A.; von Lintig, J.; Vogt, K.
NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide
Proc. Natl. Acad. Sci. USA
105
19000-19005
2008
Drosophila melanogaster (Q9VFS2), Galleria mellonella, Mus musculus
brenda
Kim, Y.-S.; Kim, N.-H.; Kim, H.-J.; Lee, J.-K.; Kim, S.-W.; Oh, D.-K.
Effective production of retinal from beta-carotene using recombinant mouse beta-carotene 15,15'-monooxygenase
Appl. Microbiol. Biotechnol.
76
1339-1345
2007
Mus musculus (Q9JJS6), Mus musculus
brenda
Voolstra, O.; Oberhauser, V.; Sumser, E.; Meyer, N.E.; Maguire, M.E.; Huber, A.; von Lintig, J.
NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors
J. Biol. Chem.
285
2130-2139
2010
Drosophila melanogaster
brenda
Lietz, G.; Lange, J.; Rimbach, G.
Molecular and dietary regulation of beta,beta-carotene 15,15-monooxygenase 1 (BCMO1)
Arch. Biochem. Biophys.
502
8-16
2010
Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Kim, Y.S.; Park, C.S.; Oh, D.K.
Hydrophobicity of residue 108 specifically affects the affinity of human beta-carotene 15,15'-monooxygenase for substrates with two ionone rings
Biotechnol. Lett.
32
847-853
2010
Homo sapiens (Q9HAY6), Homo sapiens
brenda
Vage, D.I.; Boman, I.A.
A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries)
BMC Genet.
11
10
2010
Ovis aries (C1L3B1), Ovis aries (C7C6F6), Ovis aries
brenda
Kim, Y.S.; Park, C.S.; Oh, D.K.
Retinal production from beta-carotene by beta-carotene 15,15-dioxygenase from an unculturable marine bacterium
Biotechnol. Lett.
32
957-961
2010
uncultured marine bacterium (Q4PNI0)
brenda
Kim, Y.S.; Kim, N.H.; Yeom, S.J.; Kim, S.W.; Oh, D.K.
In vitro characterization of a recombinant Blh protein from an uncultured marine bacterium as a beta-carotene 15,15-dioxygenase
J. Biol. Chem.
284
15781-15793
2009
uncultured marine bacterium (Q4PNI0)
brenda
Pham, D.N.; Leclerc, D.; Levesque, N.; Deng, L.; Rozen, R.
beta,beta-carotene 15,15'-monooxygenase and its substrate beta-carotene modulate migration and invasion in colorectal carcinoma cells
Am. J. Clin. Nutr.
98
413-422
2013
Homo sapiens (Q9HAY6), Mus musculus (Q9JJS6), Mus musculus
brenda
Kowatz, T.; Babino, D.; Kiser, P.; Palczewski, K.; von Lintig, J.
Characterization of human beta,beta-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme
Arch. Biochem. Biophys.
539
214-222
2013
Homo sapiens (Q9HAY6), Homo sapiens, Mus musculus (Q9JJS6), Mus musculus, Mus musculus C57/BL6 / 129 Sv (Q9JJS6)
brenda
Gong, X.; Marisiddaiah, R.; Rubin, L.P.
beta-Carotene regulates expression of beta-carotene 15,15'-monoxygenase in human alveolar epithelial cells
Arch. Biochem. Biophys.
539
230-238
2013
Homo sapiens (Q9HAY6)
brenda
Amengual, J.; Widjaja-Adhi, M.A.; Rodriguez-Santiago, S.; Hessel, S.; Golczak, M.; Palczewski, K.; von Lintig, J.
Two carotenoid-oxygenases contribute to mammalian pro-vitamin A metabolism
J. Biol. Chem.
288
34081-34096
2013
Mus musculus (Q9JJS6)
brenda
Dela Sena, C.; Narayanasamy, S.; Riedl, K.M.; Curley, R.W.; Schwartz, S.J.; Harrison, E.H.
Substrate specificity of purified recombinant human beta-carotene 15,15'-oxygenase (BCO1)
J. Biol. Chem.
288
37094-37103
2013
Homo sapiens (Q9HAY6)
brenda
Lietz, G.; Oxley, A.; Boesch-Saadatmandi, C.; Kobayashi, D.
Importance of beta,beta-carotene 15,15-monooxygenase 1 (BCMO1) and beta,beta-carotene 9,10-dioxygenase 2 (BCDO2) in nutrition and health
Mol. Nutr. Food Res.
56
241-250
2012
Danio rerio, Drosophila melanogaster, no activity in Arabidopsis thaliana, no activity in Zea mays, Mustela putorius furo, Oryctolagus cuniculus (G1SEP0), Cavia porcellus (H0VRY9), Rattus norvegicus (Q91XT5), Homo sapiens (Q9HAY6), Homo sapiens, Gallus gallus (Q9I993), Mus musculus (Q9JJS6)
brenda
Amengual, J.; Gouranton, E.; van Helden, Y.G.; Hessel, S.; Ribot, J.; Kramer, E.; Kiec-Wilk, B.; Razny, U.; Lietz, G.; Wyss, A.; Dembinska-Kiec, A.; Palou, A.; Keijer, J.; Landrier, J.F.; Bonet, M.L.; von Lintig, J.
Beta-carotene reduces body adiposity of mice via BCMO1
PLoS ONE
6
e20644
2011
Mus musculus (Q9JJS6)
brenda
Lee, S.A.; Jiang, H.; Trent, C.M.; Yuen, J.J.; Narayanasamy, S.; Curley, R.W.; Harrison, E.H.; Goldberg, I.J.; Maurer, M.S.; Blaner, W.S.
Cardiac dysfunction in beta-carotene-15,15-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism
Am. J. Physiol. Heart Circ. Physiol.
307
H1675-H1684
2014
Mus musculus (Q9JJS6)
brenda
Smith, J.W.; Ford, N.A.; Thomas-Ahner, J.M.; Moran, N.E.; Bolton, E.C.; Wallig, M.A.; Clinton, S.K.; Erdman, J.W.
Mice lacking beta-carotene-15,15'-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation
Am. J. Physiol. Regul. Integr. Comp. Physiol.
311
R1135-R1148
2016
Mus musculus (Q9JJS6), Mus musculus C57BL/6J (Q9JJS6)
brenda
Kim, Y.K.; Zuccaro, M.V.; Costabile, B.K.; Rodas, R.; Quadro, L.
Tissue- and sex-specific effects of beta-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice
Arch. Biochem. Biophys.
572
11-18
2015
Mus musculus (Q9JJS6), Mus musculus C57BL/6 (Q9JJS6)
brenda
Raghuvanshi, S.; Reed, V.; Blaner, W.S.; Harrison, E.H.
Cellular localization of ?-carotene 15,15 oxygenase-1 (BCO1) and beta-carotene 9,10 oxygenase-2 (BCO2) in rat liver and intestine
Arch. Biochem. Biophys.
572
19-27
2015
Rattus norvegicus (Q91XT5)
brenda
Jlali, M.; Graulet, B.; Chauveau-Duriot, B.; Godet, E.; Praud, C.; Nunes, C.S.; Le Bihan-Duval, E.; Berri, C.; Duclos, M.J.
Nutrigenetics of carotenoid metabolism in the chicken a polymorphism at the beta,beta-carotene 15,15'-mono-oxygenase 1 (BCMO1) locus affects the response to dietary beta-carotene
Br. J. Nutr.
111
2079-2088
2014
Gallus gallus
brenda
Takitani, K.; Miyazaki, H.; Koh, M.; Kishi, K.; Inoue, A.; Tamai, H.
Dehydroepiandrosterone alters retinol status and expression of the beta-carotene 15,15'-monooxygenase and lecithin retinol acyltransferase genes
J. Nutr. Sci. Vitaminol.
62
12-18
2016
Rattus norvegicus (G3V7N1), Rattus norvegicus Wistar (G3V7N1)
brenda
Yamaguchi, N.; Sunto, A.; Goda, T.; Suruga, K.
Competitive regulation of human intestinal beta-carotene 15,15'-monooxygenase 1 (BCMO1) gene expression by hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha
Life Sci.
119
34-39
2014
Homo sapiens (Q9HAY6), Homo sapiens
brenda
Takahashi, H.; Kutasy, B.; Pes, L.; Paradisi, F.; Puri, P.
Decidual beta-carotene-15,15'-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia
Pediatr. Surg. Int.
31
37-43
2015
Rattus norvegicus (A3KN98), Rattus norvegicus (Q91XT5), Rattus norvegicus Sprague–Dawley (A3KN98), Rattus norvegicus Sprague–Dawley (Q91XT5)
brenda
Culligan, E.P.; Sleator, R.D.; Marchesi, J.R.; Hill, C.
Metagenomic identification of a novel salt tolerance gene from the human gut microbiome which encodes a membrane protein with homology to a brp/blh-family beta-carotene 15,15'-monooxygenase
PLoS ONE
9
e103318
2014
uncultured bacterium
brenda
Sun, L.; Kwak, S.; Jin, Y.S.
Vitamin A production by engineered Saccharomyces cerevisiae from xylose via two-phase in situ extraction
ACS Synth. Biol.
8
2131-2140
2019
uncultured marine bacterium 66A03 (Q4PNI0)
brenda
Perez, A.A.; Gajewski, J.P.; Ferlez, B.H.; Ludwig, M.; Baker, C.S.; Golbeck, J.H.; Bryant, D.A.
Zn2+-inducible expression platform for Synechococcus sp. strain PCC 7002 based on the smtA promoter/operator and smtB repressor
Appl. Environ. Microbiol.
83
e02491-16
2017
Drosophila melanogaster (Q9VFS2)
brenda
Harrison, E.H.; Kopec, R.E.
Enzymology of vertebrate carotenoid oxygenases
Biochim. Biophys. Acta Mol. Cell Biol. Lipids
1865
158653
2020
Homo sapiens (Q9HAY6)
brenda