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1.13.11.63: beta-carotene 15,15'-dioxygenase

This is an abbreviated version!
For detailed information about beta-carotene 15,15'-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.63

Reaction

beta-carotene
+
O2
= 2 all-trans retinal

Synonyms

BC-15,15'-oxygenase, BCM, BCMO, Bcmo1, Bcmo2, BCO, BCO1, BCO2, Bcox, beta,beta-carotene 15,15'-mono-oxygenase 1, beta,beta-carotene 15,15'-monooxygenase, beta,beta-carotene 15,15'-monooxygenase 1, beta,beta-carotene 15,15'-monooxygenase-1, beta,beta-carotene 15,15-monooxygenase 1, beta,beta-carotene-15,15'-monooxygenase, beta,beta-carotene-15,15'-oxygenase, beta-carotene 15,15' oxygenase, beta-carotene 15,15'-dioxygenase, beta-carotene 15,15'-monooxygenase, beta-carotene 15,15'-monooxygenase 1, beta-carotene 15,15'-oxygenase, beta-carotene 15,15-monooxygenase, beta-carotene dioxygenase 1, beta-carotene oxygenase 2, beta-carotene-15,15'-dioxygenase, beta-carotene-15,15'-monooxygenase, beta-carotene-15,15'-oxygenase, beta-carotene-15,15'-oxygenase-1, beta-carotene-15,15'-oxygenase-2, beta-CD, betaCDIOX, betaCO, BLH, brp/blh-family beta-carotene monooxygenase, brpA, carotenoid oxygenase, Ci-BCO, CMO1, EC 1.13.11.21, EC 1.14.99.36, NinaB

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.63 beta-carotene 15,15'-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.63 - beta-carotene 15,15'-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,1'-biphenyl
-
-
1,10-phenanthroline
13-cis-retinal
-
-
15,15'-Dehydro-beta-apo-10'-carotenol
-
inhibits reaction with beta-apo-10'-carotenol
2,2'-dipyridyl
2,6-di-tert-butyl-4-methylphenol
-
0.001 mM, strong mixed-type inhibition
3,5-di-tert-butyltoluene
-
-
3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate
at 0.245%
4-chloromercuribenzoate
4-hydroxymercuribenzoate
8-hydroxyquinoline
-
-
9-cis retinoic acid
-
suppresses the upregulation by vitamin A deficiency
9-cis-retinal
-
-
all-trans retinal
-
-
all-trans retinoic acid
-
suppresses the upregulation by vitamin A deficiency
apo-8'-carotenal
-
-
astaxanthin
-
competitive
beta-carotene
-
-
butylated hydroxyanisole
-
moderate inhibition
canthaxanthin
-
mixed inhibition
curcumin
-
moderate inhibition
desferrioxamine
-
noncompetitive inhibitor
Diphenylamine
-
non-competitive inhibition
hexaethylene glycol monooctyl ether
at 0.195-0.78%
iodoacetamide
lutein
-
competitive
luteolin
-
remarkable noncompetitive inhibition
lycopene
-
competitive
N-ethylmaleimide
n-octyl-beta-D-thioglucopyranoside
at 0.56%
n-propyl gallate
-
moderate inhibition
Na-arsenite
-
-
nordihydroguaiaretic acid
-
moderate inhibition
o-Iodosobenzoate
-
-
o-phenanthroline
p-hydroxymercuribenzoate
-
-
phenanthrene
-
-
Phenanthroline
2% residual activity
phloretin
-
remarkable noncompetitive inhibition
quercetin
-
remarkable noncompetitive inhibition
retinyl acetate
-
-
Rhamnetin
-
remarkable noncompetitive inhibition
sodium arsenide
-
-
Sodium glycocholate
-
-
tetraethylene glycol monooctyl ether
at 0.125-0.5%
zeaxanthin
-
non-competitive
additional information
-