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1.13.11.63: beta-carotene 15,15'-dioxygenase

This is an abbreviated version!
For detailed information about beta-carotene 15,15'-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.63

Reaction

beta-carotene
+
O2
= 2 all-trans retinal

Synonyms

BC-15,15'-oxygenase, BCM, BCMO, Bcmo1, Bcmo2, BCO, BCO1, BCO2, Bcox, beta,beta-carotene 15,15'-mono-oxygenase 1, beta,beta-carotene 15,15'-monooxygenase, beta,beta-carotene 15,15'-monooxygenase 1, beta,beta-carotene 15,15'-monooxygenase-1, beta,beta-carotene 15,15-monooxygenase 1, beta,beta-carotene-15,15'-monooxygenase, beta,beta-carotene-15,15'-oxygenase, beta-carotene 15,15' oxygenase, beta-carotene 15,15'-dioxygenase, beta-carotene 15,15'-monooxygenase, beta-carotene 15,15'-monooxygenase 1, beta-carotene 15,15'-oxygenase, beta-carotene 15,15-monooxygenase, beta-carotene dioxygenase 1, beta-carotene oxygenase 2, beta-carotene-15,15'-dioxygenase, beta-carotene-15,15'-monooxygenase, beta-carotene-15,15'-oxygenase, beta-carotene-15,15'-oxygenase-1, beta-carotene-15,15'-oxygenase-2, beta-CD, betaCDIOX, betaCO, BLH, brp/blh-family beta-carotene monooxygenase, brpA, carotenoid oxygenase, Ci-BCO, CMO1, EC 1.13.11.21, EC 1.14.99.36, NinaB

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.63 beta-carotene 15,15'-dioxygenase

Disease

Disease on EC 1.13.11.63 - beta-carotene 15,15'-dioxygenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector.
Asthma
Dietary intake of vitamin A, lung function, and incident asthma in childhood.
Breast Neoplasms
Plasma carotenoid- and retinol-weighted gene scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Dehydration
Crystalline beta-cyclodextrin.12H2O reversibly dehydrates to beta-cyclodextrin.10.5 H2O under ambient conditions.
Evaluation of a sulfobutyl ether beta-cyclodextrin as a solubilizing/stabilizing agent for several drugs.
Diabetes Mellitus, Type 2
Expression of beta-carotene 15,15'-monooxygenase gene and retinol status in type 2 diabetic Goto-Kakizaki rats.
Dyslipidemias
Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner.
Fatty Liver
A network approach to micronutrient genetics: interactions with lipid metabolism.
Gastrointestinal Diseases
Influence of cyclodextrin complexation with NSAIDs on NSAID/cold stress-induced gastric ulceration in rats.
Hemochromatosis
Genetic Variants Influencing Biomarkers of Nutrition Are Not Associated with Cognitive Capability in Middle-Aged and Older Adults.
Liver Diseases
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice.
Lung Neoplasms
Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China.
Macular Degeneration
The relationship between BCMO1 gene variants and macular pigment optical density in persons with and without age-related macular degeneration.
Malnutrition
The reproductive and developmental toxicity profile of beta-cyclodextrin in rodents.
Microphthalmos
Photoreceptor morphology is severely affected in the beta,beta-carotene-15,15'-oxygenase (bcox) zebrafish morphant.
Neoplasms
?,?-carotene 15,15'-monooxygenase and its substrate ?-carotene modulate migration and invasion in colorectal carcinoma cells.
Plasma carotenoid- and retinol-weighted gene scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Non-alcoholic Fatty Liver Disease
Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice.
Obesity
Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner.
Pinta
NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors.
Polycystic Ovary Syndrome
The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
Prostatic Neoplasms
Plasma carotenoid- and retinol-weighted gene scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Rectal Neoplasms
Recognition ability and cytotoxicity of some oligosaccharidyl substituted beta-cyclodextrins.
Retinal Degeneration
NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors.
Vitamin A Deficiency
Carotene dioxygenase (EC 1.13.11.21) activity in rat intestine: effects of vitamin A deficiency and of pregnancy.
Conversion of beta-Carotene to Retinal Pigment.
Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression.
Molecular and dietary regulation of beta,beta-carotene 15,15'-monooxygenase 1 (BCMO1).