1.13.11.61: linolenate 9R-lipoxygenase
This is an abbreviated version!
For detailed information about linolenate 9R-lipoxygenase, go to the full flat file.
Word Map on EC 1.13.11.61
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1.13.11.61
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linoleic
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diol
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ala
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dioxygenation
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lipoxygenases
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polyunsaturated
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nostoc
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cyanobacterial
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regio
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hydroperoxides
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aspergilli
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homolytic
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allene
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terreus
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stereochemistry
- 1.13.11.61
-
linoleic
- diol
- ala
-
dioxygenation
- lipoxygenases
-
polyunsaturated
- nostoc
-
cyanobacterial
-
regio
- hydroperoxides
-
aspergilli
-
homolytic
-
allene
- terreus
-
stereochemistry
Reaction
Synonyms
(9R)-LOX, 11R-LOX, 9R-lipoxygenase, 9R-LOX, ARA 11RLOX, arachidonate 11R-lipoxygenase, CspLOX2, LA 9RLOX, linoleate 11R-lipoxygenase, linoleate 9R-dioxygenase, lipoxygenase 2, NspLOX
ECTree
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Reaction
Reaction on EC 1.13.11.61 - linolenate 9R-lipoxygenase
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alpha-linolenate + O2 = (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate
the LOX reaction is always catalyzed at a 1Z,4Z-pentadiene system of a polyunsaturated fatty acid. In the initial step, a hydrogen atom is abstracted from the central bis-allylic methylene group by the non-heme iron or in few cases manganese in the active site. During this rate-limiting step, Fe(III) is reduced to Fe(II) in the former case and a substrate radical is formed which rapidly delocalizes over the five carbon unit. Addition of dioxygen yields a peroxyl radical, which is finally reduced to the hydroperoxide product
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