1.13.11.6: 3-hydroxyanthranilate 3,4-dioxygenase

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For detailed information about 3-hydroxyanthranilate 3,4-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.6

1.13.11.6

quinolinic

kynureninase

quin

2,3-dioxygenase

3-monooxygenase

excitotoxin

phosphoribosyltransferase

kynurenine-oxoglutarate

aminocarboxymuconate-semialdehyde

kynurenic

3-hydroxykynurenine

ibotenic

epilepsy-prone

picolinic

drug development

medicine

pharmacology

Reaction

Synonyms

3-HAD, 3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxidase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3HAO, EC 1.13.1.6, HAD, HAO, oxygenase, 3-hydroxyanthranilate 3,4-di-

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.6 3-hydroxyanthranilate 3,4-dioxygenase

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Results	in table
1	Activating Compound
5583	AA Sequence
4	Application
1	CAS Registry Number
8	Cloned(Commentary)
1	Cofactor
6	Crystallization (Commentary)
24	Disease/ Diagnostics
8	General Information
2	General Stability
35	Inhibitors
8	Ki Value [mM]
18	KM Value [mM]
3	Localization
20	Metals/Ions
15	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
213	Organism
8	Pathway
39	PDB ID
6	pH Optimum
4	pH Range
2	pH Stability
2	pI Value
18	Protein Variants
13	Purification (Commentary)
4	Reaction
3	Reaction Type
36	Reference
20	Source Tissue
12	Specific Activity [micromol/min/mg]
8	Storage Stability
44	Substrates and Products (Substrate)
6	Subunits
22	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

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Application on EC 1.13.11.6 - 3-hydroxyanthranilate 3,4-dioxygenase

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drug development

2 entries

medicine

Rattus norvegicus

plays a role in disorders, associated with altered tissue levels of quinolinic acid

439371

pharmacology

Homo sapiens

P46952

the enzyme is a target for pharmacological downregulation because it is involved in formation of quinolinic acid, a highly potent excitotoxin implicated in a number of neurodegenerative conditions

741516