1.13.11.52: indoleamine 2,3-dioxygenase
This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.52
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1.13.11.52
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kynurenine
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dendritic
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t-cells
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lymphocyte
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immunotherapy
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ifn-gamma
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immunomodulatory
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autoimmune
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mesenchymal
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interferon-gamma
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tregs
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allogeneic
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immunoregulatory
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rejection
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serotonin
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heme
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monocyte
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tolerogenic
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quinolinic
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checkpoint
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neopterin
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allograft
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immunomodulation
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foxp3
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antigen-presenting
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immunoregulation
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myeloid-derived
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3-hydroxykynurenine
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ctla-4
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graft-versus-host
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l-trp
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3-hydroxyanthranilic
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quin
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tumor-infiltrating
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heme-containing
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depressive-like
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immunotherapeutic
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plasmacytoid
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5-hydroxytryptamine
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monocyte-derived
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ifn-gamma-induced
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5-hydroxyindoleacetic
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interferon-gamma-induced
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immuno-oncology
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drug development
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cd4+cd25+foxp3+
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mdscs
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pharmacology
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alloreactive
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3-monooxygenase
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ifn-gamma-mediated
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medicine
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death-ligand
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synthesis
- 1.13.11.52
- kynurenine
- dendritic
- t-cells
- lymphocyte
-
immunotherapy
- ifn-gamma
-
immunomodulatory
- autoimmune
- mesenchymal
- interferon-gamma
-
tregs
-
allogeneic
-
immunoregulatory
-
rejection
- serotonin
- heme
- monocyte
-
tolerogenic
-
quinolinic
-
checkpoint
- neopterin
-
allograft
-
immunomodulation
- foxp3
-
antigen-presenting
-
immunoregulation
-
myeloid-derived
- 3-hydroxykynurenine
-
ctla-4
- graft-versus-host
- l-trp
-
3-hydroxyanthranilic
-
quin
-
tumor-infiltrating
-
heme-containing
-
depressive-like
-
immunotherapeutic
-
plasmacytoid
- 5-hydroxytryptamine
-
monocyte-derived
-
ifn-gamma-induced
-
5-hydroxyindoleacetic
-
interferon-gamma-induced
-
immuno-oncology
- drug development
-
cd4+cd25+foxp3+
-
mdscs
- pharmacology
-
alloreactive
-
3-monooxygenase
-
ifn-gamma-mediated
- medicine
-
death-ligand
- synthesis
Reaction
Synonyms
31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein
ECTree
1.13.11.52 indoleamine 2,3-dioxygenaseAdvanced search results
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results (Turnover Number
Turnover Number on EC 1.13.11.52 - indoleamine 2,3-dioxygenase
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.161
5-methoxy-DL-tryptophan
pH 7.5, 25°C, recombinant enzyme IDO2
0.0052
1-methyl-D-tryptophan
pH 7.5, 25°C, recombinant enzyme IDO2
0.049
5-fluoro-DL-tryptophan
pH 7.5, 25°C, recombinant enzyme IDO2
0.68
5-fluoro-DL-tryptophan
H55A mutant enzyme, O2 not present at a saturating level
0.8
5-fluoro-DL-tryptophan
H55S mutant enzyme, O2 not present at a saturating level
2.4
5-fluoro-DL-tryptophan
O2 not present at a saturating level
0.025
5-hydroxy-L-tryptophan
pH 6.5, 25°C, recombinant enzyme IDO1
0.4
5-methyl-DL-tryptophan
H55A mutant enzyme, O2 not present at a saturating level
1.45
5-methyl-DL-tryptophan
H55S mutant enzyme, O2 not present at a saturating level
3.59
5-methyl-DL-tryptophan
O2 not present at a saturating level
3.78
6-fluoro-DL-tryptophan
H55A mutant enzyme, O2 not present at a saturating level
3.8
6-fluoro-DL-tryptophan
H55S mutant enzyme, O2 not present at a saturating level
37.3
6-fluoro-DL-tryptophan
O2 not present at a saturating level
0.108
6-methyl-DL-tryptophan
pH 7.5, 25°C, recombinant enzyme IDO2
1.65
6-methyl-DL-tryptophan
H55A mutant enzyme, O2 not present at a saturating level
4.66
6-methyl-DL-tryptophan
H55S mutant enzyme, O2 not present at a saturating level
0.62
L-tryptophan
pH 8.0, temperature not specified in the publication, mutant enzyme H127E
0.87
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the absence of methylene blue and cytochrome b5, in PBS buffer (pH 7.4), at 37°C
1.3
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.0001 mM methylene blue and in the absence of cytochrome b5, in PBS buffer (pH 7.4), at 37°C
1.47
L-tryptophan
pH 8.0, temperature not specified in the publication, wild-type enzyme
1.7
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the absence of methylene blue and in the presence of 250 nM cytochrome b5, in PBS buffer (pH 7.4), at 37°C
2.2
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.0001 mM methylene blue and 250 nM cytochrome b5, in PBS buffer (pH 7.4), at 37°C
2.5
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.0005 mM methylene blue and in the absence of cytochrome b5, in PBS buffer (pH 7.4), at 37°C
2.6
L-tryptophan
H55S mutant enzyme, O2 not present at a saturating level
2.86
L-tryptophan
H55A mutant enzyme, O2 not present at a saturating level
3
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.001 mM methylene blue and in the absence of cytochrome b5, in PBS buffer (pH 7.4), at 37°C
3.4
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.0005 mM methylene blue and 250 nM cytochrome b5, in PBS buffer (pH 7.4), at 37°C
3.9
L-tryptophan
pH 8.0, temperature not specified in the publication, mutant enzyme N127T
4.2
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.001 mM methylene blue and 250 nM cytochrome b5, in PBS buffer (pH 7.4), at 37°C
6.03
L-tryptophan
pH 8.0, temperature not specified in the publication, mutant enzyme E132H
6.4
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.01 mM methylene blue and in the absence of cytochrome b5, in PBS buffer (pH 7.4), at 37°C
6.5
L-tryptophan
pH 8.0, temperature not specified in the publication, wild-type enzyme
8.1
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.03 mM methylene blue and in the absence of cytochrome b5, in PBS buffer (pH 7.4), at 37°C
10
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.01 mM methylene blue and 250 nM cytochrome b5, in PBS buffer (pH 7.4), at 37°C
12
L-tryptophan
NADPH-cytochrome P450 reductase-supported oxidation, in the presence of 0.03 mM methylene blue and 250 nM cytochrome b5, in PBS buffer (pH 7.4), at 37°C
additional information
additional information
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2070 per min, formylkynurenine formed
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additional information
additional information
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420 per min, formylkynurenine formed
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