1.13.11.52: indoleamine 2,3-dioxygenase
This is an abbreviated version!
For detailed information about indoleamine 2,3-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.52
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1.13.11.52
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kynurenine
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dendritic
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t-cells
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lymphocyte
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immunotherapy
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ifn-gamma
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immunomodulatory
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autoimmune
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mesenchymal
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interferon-gamma
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tregs
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allogeneic
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immunoregulatory
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rejection
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serotonin
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heme
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monocyte
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tolerogenic
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quinolinic
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checkpoint
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neopterin
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allograft
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immunomodulation
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foxp3
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antigen-presenting
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immunoregulation
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myeloid-derived
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3-hydroxykynurenine
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ctla-4
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graft-versus-host
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l-trp
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3-hydroxyanthranilic
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quin
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tumor-infiltrating
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heme-containing
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depressive-like
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immunotherapeutic
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plasmacytoid
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5-hydroxytryptamine
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monocyte-derived
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ifn-gamma-induced
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5-hydroxyindoleacetic
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interferon-gamma-induced
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immuno-oncology
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drug development
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cd4+cd25+foxp3+
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mdscs
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pharmacology
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alloreactive
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3-monooxygenase
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ifn-gamma-mediated
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medicine
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death-ligand
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synthesis
- 1.13.11.52
- kynurenine
- dendritic
- t-cells
- lymphocyte
-
immunotherapy
- ifn-gamma
-
immunomodulatory
- autoimmune
- mesenchymal
- interferon-gamma
-
tregs
-
allogeneic
-
immunoregulatory
-
rejection
- serotonin
- heme
- monocyte
-
tolerogenic
-
quinolinic
-
checkpoint
- neopterin
-
allograft
-
immunomodulation
- foxp3
-
antigen-presenting
-
immunoregulation
-
myeloid-derived
- 3-hydroxykynurenine
-
ctla-4
- graft-versus-host
- l-trp
-
3-hydroxyanthranilic
-
quin
-
tumor-infiltrating
-
heme-containing
-
depressive-like
-
immunotherapeutic
-
plasmacytoid
- 5-hydroxytryptamine
-
monocyte-derived
-
ifn-gamma-induced
-
5-hydroxyindoleacetic
-
interferon-gamma-induced
-
immuno-oncology
- drug development
-
cd4+cd25+foxp3+
-
mdscs
- pharmacology
-
alloreactive
-
3-monooxygenase
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ifn-gamma-mediated
- medicine
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death-ligand
- synthesis
Reaction
Synonyms
31854, BRAFLDRAFT_126354, CG5163, EC 1.13.1.12, hIDO, hIDO1, hTDO, IDO, IDO-1, IDO-2, IDO-I, IDO-II, IDO-III, IDO-IV, IDO1, IDO2, INDO, INDOL1, indolamine 2,3-dioxygenase, indole 2,3-dioxygenase, indoleamine 2, 3-dioxygenase, indoleamine 2,3 dioxygenase, indoleamine 2,3-dioxygenase, indoleamine 2,3-dioxygenase 1, indoleamine 2,3-dioxygenase 2, indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein, indoleamine-2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase, L-tryptophan 2,3-dioxygenase, L-tryptophan pyrrolase, mIDO, oxygenase, tryptophan 2,3-di-, proto-IDO, proto-indoleamine 2,3-dioxygenase, superoxygenase, TDO, TDO2, TioF, TO, TRPO, Tryptamin 2,3-dioxygenase, tryptamine 2,3-dioxygenase, tryptophan 2,3-dioxygenase, tryptophan dioxygenase, tryptophan oxygenase, tryptophan peroxidase, tryptophan pyrrolase, tryptophan-2,3-dioxygenase, tryptophanase, v1g244579, Vermilion protein
ECTree
1.13.11.52 indoleamine 2,3-dioxygenaseAdvanced search results
results (
results (KI Value
KI Value on EC 1.13.11.52 - indoleamine 2,3-dioxygenase
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Ki VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.000061
(3R,4S and 3S,4R)-4-(butylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
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0.00007
(3S,4S and 3R,4R)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
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0.000066
(3S,4S)-4-(benzylamino)-3,9-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-benzo[g]chromene-5,10-dione
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0.18
6-nitro-L-tryptophan
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1 mM, competitive inhibition, 52% inhibition relative to L-tryptophan, 50 mM potassium phosphate, pH 6.5, 10 mM ascorbic acid, 0.01 mM methylene blue, 0.1 mg catalase, 37°C, 10 min
0.0015
imidodicarbonimidic diamide, N-methyl-N''-9-phenanthrenyl-, monohydrochloride
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0.0018
tenatoprazole
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IDO2, pH and temperature not specified in the publication
0.367
[4-(1,4-dioxido-1,2,4-benzotriazin-3-yl)aminobutyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
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0.0871
[4-(1-oxido-1,2,4-benzotriazin-3-yl)aminobutyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
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0.197
[5-(1,4-dioxido-1,2,4-benzotriazin-3-yl)aminopentyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
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0.0763
[5-(1-oxido-1,2,4-benzotriazin-3-yl)aminopentyl]-(2S)-N-tert-butoxycarbonyl-2-amino-(1-methyl-indole-3-yl)propanamide
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11.3
1-methyl-D-tryptophan
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recombinant isozyme IDO1, in the presence of 0.01 mM methylene blue, in 100 mM phosphate buffer, pH 7.4, at 37°C
0.019
1-methyl-L-tryptophan
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pH and temperature not specified in the publication
0.08
1-methyl-L-tryptophan
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recombinant isozyme IDO1, in the presence of 50 nM recombinant human cytochrome b5 and 50 nM NADPH cytochrome P450 reductase, in 100 mM phosphate buffer, pH 7.4, at 37°C
0.105
1-methyl-L-tryptophan
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recombinant isozyme IDO1, in the presence of 0.01 mM methylene blue, in 100 mM phosphate buffer, pH 7.4, at 37°C
0.44
1-methyl-L-tryptophan
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recombinant isozyme IDO2, in the presence of 50 nM recombinant human cytochrome b5 and 50 nM NADPH cytochrome P450 reductase, in 100 mM phosphate buffer, pH 7.4, at 37°C
2.75
1-methyl-L-tryptophan
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recombinant isozyme IDO1, in the presence of 0.01 mM methylene blue, in 100 mM phosphate buffer, pH 7.4, at 37°C
0.05
D-tryptophan
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0.1 M potassium phosphate buffer (pH 6-8), 0.025 mM methylene blue, 0.2 mg catalase, 10 mM ascorbic acid, 50 nM dioxygenase, 25°C
1.6
L-tryptophan
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inhibition of IDO1, pH and temperature not specified in the publication
0.69
norharman
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recombinant isozyme IDO1, in the presence of 0.01 mM methylene blue, in 100 mM phosphate buffer, pH 7.4, at 37°C
1.08
norharman
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recombinant isozyme IDO1, in the presence of 0.01 mM methylene blue, in 100 mM phosphate buffer, pH 7.4, at 37°C
1.73
norharman
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recombinant isozyme IDO1, in the presence of 50 nM recombinant human cytochrome b5 and 50 nM NADPH cytochrome P450 reductase, in 100 mM phosphate buffer, pH 7.4, at 37°C
1.96
norharman
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recombinant isozyme IDO2, in the presence of 50 nM recombinant human cytochrome b5 and 50 nM NADPH cytochrome P450 reductase, in 100 mM phosphate buffer, pH 7.4, at 37°C
additional information
additional information
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review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase
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additional information
additional information
review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase
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