1.13.11.5: homogentisate 1,2-dioxygenase
This is an abbreviated version!
For detailed information about homogentisate 1,2-dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.5
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1.13.11.5
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alkaptonuria
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ochronosis
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urine
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joint
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cartilage
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arthropathy
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sclera
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nitisinone
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arthroplasty
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discoloration
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darken
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maleylacetoacetate
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melanin-like
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calculi
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pyomelanin
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ultra-rare
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4-hydroxyphenylpyruvate
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slovakia
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medicine
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ntbc
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diagnostics
- 1.13.11.5
- alkaptonuria
-
ochronosis
- urine
- joint
- cartilage
- arthropathy
- sclera
- nitisinone
-
arthroplasty
-
discoloration
-
darken
- maleylacetoacetate
-
melanin-like
-
calculi
-
pyomelanin
-
ultra-rare
- 4-hydroxyphenylpyruvate
-
slovakia
- medicine
- ntbc
- diagnostics
Reaction
Synonyms
EC 1.13.1.5, EC 1.99.2.5, ElHDO, HgD, HGDO, HGO, HGOa, HGOb, HmgA, homogentisate 1,2 dioxigenase, homogentisate 1,2 dioxygenase, homogentisate 1,2-dioxygenase, homogentisate dioxygenase, homogentisate oxidase, homogentisate oxygenase, homogentisate phytyl-transferase, homogentisic acid 1,2-dioxygenase, homogentisic acid oxidase, homogentisic acid oxygenase, homogentisic oxygenase, homogentisicase, HPT, HTO
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Source Tissue
Source Tissue on EC 1.13.11.5 - homogentisate 1,2-dioxygenase
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low level expression within developing male germ cells within the testis and epididymis in Hgd tm1a -/-
additional information
primary culture, alkaptonuria chondrocytes show a 10% increase of the enzyme expression compared to normal ones
liver has the highest expression of Hgd. Homogentisate 1,2-dioxygenase deficiency in the liver is responsible for homogentisic acid derived ochronotic pigmentation
tissue distribution of HGD, semi-quantitative RT-PCR analysis, overview
additional information
enzyme expression analysis in human normal and alkaptonuria chondrocytes, synoviocytes, osteoblasts as well as in human osteosarcoma cells, overview
additional information
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enzyme expression analysis in human normal and alkaptonuria chondrocytes, synoviocytes, osteoblasts as well as in human osteosarcoma cells, overview
additional information
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not in cardiac and skeletal muscle, brain, spleen, intestine, pancreas, salivary gland, germinal epithelium, blood