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1.13.11.45: linoleate 11-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 11-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.45

Reaction

linoleate
+
O2
=
(9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate

Synonyms

13 R -MnLOX, 13R-MnLOX, Cg-MnLOX, CspLOX2, Fo-MnLOX, linoleate dioxygenase, lipoxygenase 2, LOX-1, manganese lipoxygenase, manganese LOX, MGG_08499, Mn-LO, Mn-LOX, MnLOX, Mo-MnLOX

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.45 linoleate 11-lipoxygenase

Inhibitors

Inhibitors on EC 1.13.11.45 - linoleate 11-lipoxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
arachidonic acid
-
inhibits at 0.01 mM
eicosatetraynoic acid
N-(3-phenoxycinnamyl) acetohydroxamic acid
0.3 mM, complete inhibition
N-(3-phenoxycinnamyl)acetohydroxamic acid
-
50% of control activity at 0.05 mM
Tween 20
-
inhibition of Ca2+-activated enzyme at pH 7.5 and 6.4, no inhibition at pH 6.4 in the absence of Ca2+
additional information
-
no inhibition by lipoxygenase inhibitors zileuton, esculetin and ICI 230487
-