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1.13.11.39: biphenyl-2,3-diol 1,2-dioxygenase

This is an abbreviated version!
For detailed information about biphenyl-2,3-diol 1,2-dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.39

Reaction

biphenyl-2,3-diol
+
O2
=
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate

Synonyms

2'-aminobiphenyl-2,3-diol 1,2-dioxygenase, 2,3-DBDO, 2,3-DBPD, 2,3-DHBD, 2,3-DHBP dioxygenase, 2,3-dihydroxy-biphenyl 1,2-dioxygenase, 2,3-dihydroxybiphenyl 1,2-dioxygenase, 2,3-dihydroxybiphenyl dioxygenase, 2,3-dihydroxybiphenyl-1,2-dioxygenase, 2,3-dihydroxybiphenyl:oxygen 1,2 oxidoreductase, 2,3-diOH-biphenyl 1,2-dioxygenase, 2,3DHBD, 2-aminobiphenyl-2,3-diol-1,2-dioxygenase, 23 OHBP oxygenase, 3-phenylcatechol dioxygenase, biphenyl-2,3-diol dioxygenase, BPDO, BphC, BphC1, BphC1-BN6, BphC2, BphC2-BN6, BphC3, bphC5, BphCLA-4, BphC_JF8, BphC_LA-4, C23o, CarB, CarBaBb, DHB12O, DHBD, EtbC, manganese(II)-dependent 2,3-dihydroxybiphenyl 1,2-dioxygenase, RrbphCI

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase

Inhibitors

Inhibitors on EC 1.13.11.39 - biphenyl-2,3-diol 1,2-dioxygenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
2,3-Dihydroxybiphenyl
2-Hydroxypyridine N-oxide
-
0.2 mM
3,4-dihydroxybiphenyl
-
strain CB406, inactivation in presence of O2
3-chlorocatechol
3-ethylcatechol
-
reversible substrate inhibition
3-methylcatechol
-
-
4-Chlorocatechol
-
-
4-methylcatechol
-
-
8-hydroxyquinoline
5 mM 30 min
acetone
-
competitive inhibition
alpha,alpha'-dipyridyl
-
inhibits catalysis, but protects the Fe2+ from oxidative inactivation
Ba2+
1 mM, moderate inhibition
diethyldithiocarbamic acid
5 mM 30 min
Hg2+
1 mM, complete inhibition
iodoacetic acid
5 mM 30 min
isopropylalcohol
-
-
L-ascorbic acid
completely inhibits at concentrations over 25 mM
N-ethylmaleimide
5 mM 30 min
Ni2+
1 mM, strong inhibition
o-phenanthroline
-
-
tert-butanol
-
-
Zn2+
1 mM, complete inhibition with substrate biphenyl-2,3-diol, not with catechols
additional information
-
do not cleave 3,4-dihydroxybiphenyl, but is not inactivated
-