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0.0289 - 0.136
(16(R),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0227 - 0.0236
(16(S),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0368 - 0.293
(17(R),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0313 - 0.236
(17(S),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
0.0083
1-linoleoyl lysophosphatidic acid
-
pH 7.4, 25°C
0.0175
1-linoleoyl lysophosphatidylcholine
-
pH 7.4, 25°C
0.0009 - 0.0067
4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid
-
0.0017 - 0.057
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid
-
0.0017 - 0.029
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
-
0.00095 - 0.013
arachidonate
0.0025 - 1.1
arachidonic acid
0.09
dilinoleoyl phosphatidic acid
-
pH 7.4, 25°C
0.0717
dilinoleoyl phosphatidylcholine
-
pH 7.4, 25°C
0.003 - 0.0772
linoleic acid
0.01
lipoic acid
-
splice variant 15-LOb1
additional information
additional information
-
0.0289
(16(R),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, wild-type enzyme
0.136
(16(R),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, mutant enzyme F353L
0.0227
(16(S),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, mutant enzyme F353L
0.0236
(16(S),5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, wild-type enzyme
0.0368
(17(R),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, mutant enzyme L353L
0.293
(17(R),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, wild-type enzyme
0.0313
(17(S),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, mutant enzyme L353L
0.236
(17(S),5Z,8Z,11Z,14Z)-17-hydroxyeicosa-5,8,11,14-tetraenoic acid
pH 7.4, wild-type enzyme
0.0009
4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid
pH 7.5, 25°C
-
0.0067
4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid
pH 7.5, 25°C
-
0.0017
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
0.0078
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
0.057
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
0.0017
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
0.0049
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
0.029
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
0.00095
arachidonate
pH 7.5, 25°C
0.0022
arachidonate
-
in HEPES buffer at 23°C
0.0027
arachidonate
pH 7.5, 25°C
0.0033
arachidonate
pH 7.5, temperature not specified in the publication
0.005
arachidonate
pH 7.5, temperature not specified in the publication
0.012
arachidonate
pH 6.5-7.0, 22°C, recombinant His6-tagged enzyme
0.013
arachidonate
pH 7.5, 22°C, recombinant His6-tagged enzyme
0.0025
arachidonic acid
-
13,13-dideuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1
0.0028
arachidonic acid
-
10,10,13,13-tetradeuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1
0.00301
arachidonic acid
pH 7.4, wild-type enzyme
0.0034
arachidonic acid
-
10,10-dideuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1
0.0037
arachidonic acid
-
unlabeled substrate, pH 7.5, 25°C, recombinant isozyme 15-hLO-1
0.0038
arachidonic acid
-
-
0.0087
arachidonic acid
pH 7.4, mutant enzyme F353L
0.0106
arachidonic acid
-
-
0.012
arachidonic acid
-
-
0.025
arachidonic acid
-
-
0.025
arachidonic acid
-
splice variant 15-LOb1
0.028
arachidonic acid
-
-
0.0631
arachidonic acid
-
-
0.068
arachidonic acid
-
-
1.1
arachidonic acid
-
splice variant 15-LOb2
0.003
linoleic acid
-
-
0.007
linoleic acid
pH 6.5, 22°C, recombinant His6-tagged enzyme
0.0121
linoleic acid
-
pH 7.4, 25°C
0.0235
linoleic acid
-
in HEPES buffer at 23°C
0.0052
O2
-
pH 7.4, wild-type enzyme, with substrate linoleic acid
0.007
O2
-
pH 7.4, mutant L367W, with substrate linoleic acid
0.009
O2
-
pH 7.4, mutant L367E, with substrate linoleic acid
0.009
O2
-
pH 7.4, mutant L367K, with substrate linoleic acid
0.0096
O2
-
with linoleic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C
0.015
O2
-
with arachidonic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C, in the presence of 12(S)-hydroperoxyeicosatetraenoic acid
0.022
O2
-
with linoleic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C, in the presence of 12(S)-hydroperoxyeicosatetraenoic acid
0.024
O2
-
with arachidonic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C
0.0401
O2
-
pH 7.4, mutant L367F, with substrate linoleic acid
additional information
additional information
-
free-energy distribution for oxygen inside the substrate-free rabbit 12/15-LOX, containing four nested free-energy isosurfaces with different energy levels, overview
-
additional information
additional information
-
kinetics with lysophospholipid substrates
-
additional information
additional information
-
steady-state kinetics of isozymes 15-hLO-1 and 15-hLO-2 with arachidonate and linoleic acid in presence or absence of 0.2% sodium cholate, or of oxygenated fatty acids, overview
-
additional information
additional information
Michaelis-Menten steady-state kinetics
-
additional information
additional information
-
Michaelis-Menten steady-state kinetics
-