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1.13.11.33: arachidonate 15-lipoxygenase

This is an abbreviated version!
For detailed information about arachidonate 15-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.33

Reaction

arachidonate
+
O2
=
(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate

Synonyms

12/15 lipoxygenase, 12/15 Lox, 12/15-lipoxygenase, 12/15-LO, 12/15-LOX, 12/15LO, 15(S)-lipoxygenase-1, 15-hLO, 15-hLO-1, 15-hLO-2, 15-lipoxygenase, 15-lipoxygenase 1, 15-lipoxygenase 2, 15-lipoxygenase type 1, 15-lipoxygenase type 2, 15-lipoxygenase type-1, 15-lipoxygenase-1, 15-lipoxygenase-2, 15-lipoxygenase-I, 15-LO, 15-LO-1, 15-LO-2, 15-LO-I, 15-LOX, 15-LOX type 1, 15-LOX-1, 15-LOX-2, 15-LOX-A, 15-LOX2, 15-rLO, 15-rLO-1, 15-sLO, 15LO1, 15S-lipoxygenase, 15S-LOX1, ALOX12, Alox15, ALOX15-2, ALOX15B, arachidonate 12/15-lipoxygenase, arachidonate 15-lipoxygenase, arachidonate 15-lipoxygenase-1, arachidonic acid 15-lipoxygenase, arachidonic acid 15-lipoxygenase-1, cardiac 12/15-LOX, endothelial 15-lipoxygenase-1, epidermis-type 15-LOX, human prostate epithelial 15-lipoxygenase-2, linoleic acid omega-6-lipoxygenase, lipoxygenase L-1, lipoxygenase-1, LO-1, LOX-1, LOX2, LOX2:Hv:1, LoxA, More, omega-6 lipoxygenase, oxygenase, arachidonate 15-lip-, reticulocyte 15-lipoxygenase-1, reticulocyte 15-LOX, reticulocyte-type 15-human lipoxygenase, reticulocyte-type 15-lipoxygenase, reticulocyte-type 15-LO-1, reticulocyte-type of 15-LOX-1, SLO, soybean 15-lipoxygenase, soybean lipoxygenase-3

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.33 arachidonate 15-lipoxygenase

KCat KM Value

KCat KM Value on EC 1.13.11.33 - arachidonate 15-lipoxygenase

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
360 - 14000
4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid
-
0.00021
5S,15S-dihydroperoxyeicosatetraenoic acid
pH 7.5, temperature not specified in the publication
-
35 - 230
5S-hydroperoxy-6E,8Z,10E,14Z-eicosatetraenoic acid
-
72 - 5800
5S-hydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid
-
0.0066 - 19000
arachidonate
0.00005 - 8
arachidonic acid
0.0038
linoleic acid
pH 6.5, 22°C, recombinant His6-tagged enzyme
240 - 790
O2