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1.13.11.27: 4-hydroxyphenylpyruvate dioxygenase

This is an abbreviated version!
For detailed information about 4-hydroxyphenylpyruvate dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.27

Reaction

4-hydroxyphenylpyruvate
+
O2
=
homogentisate
+
CO2

Synonyms

4-HPPD, 4-hydroxyphenylpyruvare dioxygenase, 4-hydroxyphenylpyruvate dioxygenase, 4-hydroxyphenylpyruvic acid dioxygenase, 4HPPD, ASJ32_19370, At-HPPD, AtHPPD, AvHPPD-03, EC 1.14.2.2, EC 1.99.1.14, formerly, F Alloantigen, F protein, F-antigen homolog, HPD, hpdA, HPPD, HPPDase, Legiolysin, MsHPPD, oxygenase, 4-hydroxyphenylpyruvate di-, p-hydroxyphenyl pyruvate dioxygenase, p-hydroxyphenylpyruvate dioxygenase, p-hydroxyphenylpyruvate hydroxylase, p-hydroxyphenylpyruvate oxidase, p-hydroxyphenylpyruvic acid hydroxylase, p-hydroxyphenylpyruvic hydroxylase, p-hydroxyphenylpyruvic oxidase, PTO1369, Pt_Hpd, T-cell reactive protein, TF-AG, YS103B

ECTree

     1 Oxidoreductases
         1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)
             1.13.11 With incorporation of two atoms of oxygen
                1.13.11.27 4-hydroxyphenylpyruvate dioxygenase

Reference

Reference on EC 1.13.11.27 - 4-hydroxyphenylpyruvate dioxygenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Buckthal, D.J.; Roche, P.A.; Moorehead, T.J.; Forbes, B.J.R.; Hamilton, G.A.
4-Hydroxyphenylpyruvate dioxygenase from pig liver
Methods Enzymol.
142
132-138
1987
Sus scrofa
Manually annotated by BRENDA team
Lindstedt, S.; Odelhoeg, B.
4-Hydroxyphenylpyruvate dioxygenase from human liver
Methods Enzymol.
142
139-142
1987
Homo sapiens
Manually annotated by BRENDA team
Lindstedt, S.; Odelhoeg, B.
4-Hydroxyphenylpyruvate dioxygenase from Pseudomonas
Methods Enzymol.
142
143-148
1987
Pseudomonas sp., Pseudomonas sp. P.J. 874
Manually annotated by BRENDA team
Fellmann, J.H.
4-Hydroxyphenylpyruvate dioxygenase from avian liver
Methods Enzymol.
142
148-154
1987
Gallus gallus
Manually annotated by BRENDA team
Bradley, F.C.; Lindstedt, S.; Lipscomb, J.D.; Que, L.; Lawrence, A.; Rundgren, M.
4-Hydroxyphenylpyruvate dioxygenase is an iron-tyrosinate protein
J. Biol. Chem.
261
11693-11698
1986
Pseudomonas sp., Pseudomonas sp. P.J. 874
Manually annotated by BRENDA team
Pascal, R.A.; Oliver, M.A.; Chen, Y.C.J.
Alternate substrates and inhibitors of bacterial 4-hydroxyphenylpyruvate dioxygenase
Biochemistry
24
3158-3165
1985
Pseudomonas sp., Pseudomonas sp. P.J. 874
Manually annotated by BRENDA team
Rundgren, M.
Some kinetic properties of 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P.J. 874
Eur. J. Biochem.
133
657-663
1983
Pseudomonas sp., Pseudomonas sp. P.J. 874
Manually annotated by BRENDA team
Evans, P.J.
A nonenzymic oxygen uptake and its implications in the assay of 4-hydroxyphenylpyruvate dioxygenase by an oxygen electrode
Experientia
39
274-275
1983
Sus scrofa
Manually annotated by BRENDA team
Lindstedt, S.; Rundgren, M.
Blue color, metal content, and substrate binding in 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P. J. 874
J. Biol. Chem.
257
11922-11931
1982
Pseudomonas sp.
Manually annotated by BRENDA team
Lindstedt, S.; Rundgren, M.
Inhibition of 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. strain P.J. 874 the enol tautomer of the substrate
Biochim. Biophys. Acta
704
66-74
1982
Pseudomonas sp., Pseudomonas sp. P.J. 874
Manually annotated by BRENDA team
Roche, P.A.; Moorehead, T.J.; Hamilton, G.A.
Purification and properties of hog liver 4-hydroxyphenylpyruvate dioxygenase
Arch. Biochem. Biophys.
216
62-73
1982
Sus scrofa
Manually annotated by BRENDA team
Muehl, H.; Loeffelhardt, W.
4-Hydroxyphenylpyruvate dioxygenase is bound to thylakoid membranes from the cyanobacterium Anacystis nidulans
FEMS Microbiol. Lett.
13
9-12
1982
Synechococcus elongatus PCC 7942 = FACHB-805
-
Manually annotated by BRENDA team
Lin, Y.L.; Huang, J.L.; Wu, C.S.; Liu, H.G.; Yang, D.Y.
Design, synthesis, and evaluation of postulated transient intermediate and substrate analogues as inhibitors of 4-hydroxyphenylpyruvate dioxygenase
Bioorg. Med. Chem. Lett.
12
1709-1713
2002
Echinochloa crus-galli, Sus scrofa
Manually annotated by BRENDA team
Lindblad, B.; Lindstedt, G.; Lindstedt, S.; Rundgren, M.
Purification and some properties of human 4-hydroxyphenylpyruvate dioxygenase (I)
J. Biol. Chem.
252
5073-5084
1977
Homo sapiens
Manually annotated by BRENDA team
Rundgren, M.
Multiple forms of human 4-hydroxyphenylpyruvate dioxygenase (II)
J. Biol. Chem.
252
5085-5093
1977
Homo sapiens
Manually annotated by BRENDA team
Rundgren, M.
Steady state kinetics of 4-hydroxyphenylpyruvate dioxygenase from human liver (III)
J. Biol. Chem.
252
5094-5099
1977
Homo sapiens
Manually annotated by BRENDA team
Lindstedt, S.; Odelhoeg, B.; Rundgren, M.
Purification and some properties of 4-hydroxyphenylpyruvate dioxygenase from Pseudomonas sp. P. J. 874
Biochemistry
16
3369-3377
1977
Pseudomonas sp., Pseudomonas sp. P.J. 874
Manually annotated by BRENDA team
Nakai, C.; Nozaki, M.; Hayaishi, O.
Studies on a possible reaction intermediate of p-hydroxyphenylpyruvate dioxygenase
Biochem. Biophys. Res. Commun.
67
590-595
1975
Bos taurus
Manually annotated by BRENDA team
Wada, G.H.; Fellman, J.H.; Fujita, T.S.; Roth, E.S.
Purification and properties of avian liver p-hydroxyphenylpyruvate hydroxylase
J. Biol. Chem.
250
6720-6726
1975
Gallus gallus
Manually annotated by BRENDA team
Garcia, I.; Rodgers, M.; Lenne, C.; Rolland, A.; Sailland, A.; Matringe, M.
Subcellular localization and purification of a p-hydroxyphenylpyruvate dioxygenase from cultured carrot cells and characterization of the corresponding cDNA
Biochem. J.
325
761-769
1997
Daucus carota
-
Manually annotated by BRENDA team
Abbott, M.T.; Udenfriend, S.
alpha-Ketoglutarate-coupled dioxygenases
Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York
167-214
1974
Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Oryctolagus cuniculus, Frog, Homo sapiens, Platyrrhini, Oncorhynchus mykiss, Didelphidae, Rattus norvegicus, Sus scrofa
-
Manually annotated by BRENDA team
Fellman, J.H.; Fujita, T.S.; Roth, E.S.
Assay, properties and tissue distribution of p-hydroxyphenylpyruvate hydroxylase
Biochim. Biophys. Acta
284
90-100
1972
Platyrrhini, Oncorhynchus mykiss, Didelphidae, Rattus norvegicus
Manually annotated by BRENDA team
La Du, B.N.; Zannoni, V.G.
The tyrosine oxidation system of liver
J. Biol. Chem.
219
273-281
1956
Canis lupus familiaris
Manually annotated by BRENDA team
Barta, I.C.; Boeger, P.
Purification and characterization of 4-hydroxyphenylpyruvate dioxygenase from maize
Pestic. Sci.
48
109-116
1996
Zea mays
-
Manually annotated by BRENDA team
Forbes, B.J.R.; Hamilton, G.A.
Mechanism and mechanism-based inactivation of 4-hydroxyphenylpyruvate dioxygenase
Bioorg. Chem.
22
343-361
1994
Sus scrofa
-
Manually annotated by BRENDA team
Ellis, M.K.; Whitfield, A.C.; Gowans, L.A.; Auton, T.R.; Provan, W.M.; Lock, E.A.; Lee, D.L.; Smith, L.L.
Characterization of the interaction of 2-[2-nitro-4-(trifluoromethyl)benzoyl]-4,4,6,6-tetramethylcyclohexane-1,3,5-trione with rat hepatic 4-hydroxyphenylpyruvate dioxygenase
Chem. Res. Toxicol.
9
24-27
1996
Rattus norvegicus
Manually annotated by BRENDA team
Aarenstrup, L.; Falch, A.M.; Jakobsen, K.K.; Neve, S.; Henriksen, L.L.; Tommerup, N.; Leffers, H.; Kristiansen, K.
Expression and post-translational modification of human 4-hydroxy-phenylpyruvate dioxygenase
Cell Biol. Int.
26
615-625
2002
Homo sapiens
Manually annotated by BRENDA team
Serre, L.; Sailland, A.; Sy, D.; Boudec, P.; Rolland, A.; Pebay-Peyroula, E.; Cohen-Addad, C.
Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway
Structure Fold. Des.
7
977-988
1999
Pseudomonas sp.
Manually annotated by BRENDA team
Garcia, I.; Job, D.; Matringe, M.
Inhibition of p-hydroxyphenylpyruvate dioxygenase by the diketonitrile of isoxaflutole: A case of half-site reactivity
Biochemistry
39
7501-7507
2000
Daucus carota
Manually annotated by BRENDA team
Ellis, M.K.; Whitfield, A.C.; Gowans, L.A.; Auton, T.R.; Provan, W.M.; Lock, E.A.; Smith, L.L.
Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione
Toxicol. Appl. Pharmacol.
133
12-19
1995
Rattus norvegicus
Manually annotated by BRENDA team
Garcia, I.; Rodgers, M.; Pepin, R.; Hsieh, T.F.; Matringe, M.
Characterization and subcellular compartmentation of recombinant 4-hydroxyphenylpyruvate dioxygenase from Arabidopsis in transgenic tobacco
Plant Physiol.
119
1507-1516
1999
Arabidopsis sp.
Manually annotated by BRENDA team
Kavana, M.; Moran, G.R.
Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione
Biochemistry
42
10238-10245
2003
Streptomyces avermitilis
Manually annotated by BRENDA team
Johnson-Winters, K.; Purpero, V.M.; Kavana, M.; Nelson, T.; Moran, G.R.
(4-Hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis: the basis for ordered substrate addition
Biochemistry
42
2072-2080
2003
Streptomyces avermitilis
Manually annotated by BRENDA team
Yang, C.; Pflugrath, J.W.; Camper, D.L.; Foster, M.L.; Pernich, D.J.; Walsh, T.A.
Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases
Biochemistry
43
10414-10423
2004
Rattus norvegicus (P32755), Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Borowski, T.; Bassan, A.; Siegbahn, P.E.
4-Hydroxyphenylpyruvate dioxygenase: a hybrid density functional study of the catalytic reaction mechanism
Biochemistry
43
12331-12342
2004
Pseudomonas fluorescens
Manually annotated by BRENDA team
Brownlee, J.M.; Johnson-Winters, K.; Harrison, D.H.; Moran, G.R.
Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC
Biochemistry
43
6370-6377
2004
Streptomyces avermitilis (Q53586)
Manually annotated by BRENDA team
Gunsior, M.; Ravel, J.; Challis, G.L.; Townsend, C.A.
Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and Evidence for the proposed benzene oxide intermediate in homogentisate formation
Biochemistry
43
663-674
2004
Streptomyces avermitilis (Q53586), Streptomyces avermitilis
Manually annotated by BRENDA team
Neve, S.; Aarenstrup, L.; Tornehave, D.; Rahbek-Nielsen, H.; Corydon, T.J.; Roepstorff, P.; Kristiansen, K.
Tissue distribution, intracellular localization and proteolytic processing of rat 4-hydroxyphenylpyruvate dioxygenase
Cell Biol. Int.
27
611-624
2003
Rattus norvegicus (P32755)
Manually annotated by BRENDA team
Falk, J.; Andersen, G.; Kernebeck, B.; Krupinska, K.
Constitutive overexpression of barley 4-hydroxyphenylpyruvate dioxygenase in tobacco results in elevation of the vitamin E content in seeds but not in leaves
FEBS Lett.
540
35-40
2003
Hordeum vulgare
Manually annotated by BRENDA team
Neidig, M.L.; Kavana, M.; Moran, G.R.; Solomon, E.I.
CD and MCD studies of the non-heme ferrous active site in (4-hydroxyphenyl)pyruvate dioxygenase: correlation between oxygen activation in the extradiol and alpha-KG-dependent dioxygenases
J. Am. Chem. Soc.
126
4486-4487
2004
Streptomyces avermitilis
Manually annotated by BRENDA team
Fritze, I.M.; Linden, L.; Freigang, J.; Auerbach, G.; Huber, R.; Steinbacher, S.
The crystal structures of Zea mays and Arabidopsis 4-hydroxyphenylpyruvate dioxygenase
Plant Physiol.
134
1388-1400
2004
Arabidopsis thaliana, Zea mays
Manually annotated by BRENDA team
Johnson-Winters, K.; Purpero, V.M.; Kavana, M.; Moran, G.R.
Accumulation of multiple intermediates in the catalytic cycle of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis
Biochemistry
44
7189-7199
2005
Streptomyces avermitilis
Manually annotated by BRENDA team
Purpero, V.M.; Moran, G.R.
Catalytic, noncatalytic, and inhibitory phenomena: kinetic analysis of (4-hydroxyphenyl)pyruvate dioxygenase from Arabidopsis thaliana
Biochemistry
45
6044-6055
2006
Arabidopsis thaliana
Manually annotated by BRENDA team
Falk, J.; Brosch, M.; Schaefer, A.; Braun, S.; Krupinska, K.
Characterization of transplastomic tobacco plants with a plastid localized barley 4-hydroxyphenylpyruvate dioxygenase
J. Plant Physiol.
162
738-742
2005
Hordeum vulgare (O48604), Hordeum vulgare
Manually annotated by BRENDA team
Dufourmantel, N.; Dubald, M.; Matringe, M.; Canard, H.; Garcon, F.; Job, C.; Kay, E.; Wisniewski, J.P.; Ferullo, J.M.; Pelissier, B.; Sailland, A.; Tissot, G.
Generation and characterization of soybean and marker-free tobacco plastid transformants over-expressing a bacterial 4-hydroxyphenylpyruvate dioxygenase which provides strong herbicide tolerance
Plant Biotechnol. J.
5
118-133
2007
Pseudomonas fluorescens
Manually annotated by BRENDA team
Lederer, B.; Boeger, P.
Recombinant p-hydroxyphenylpyruvate dioxygenase of high activity
Z. Naturforsch. C
60
549-556
2005
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Lee, C.M.; Yeo, Y.S.; Lee, J.H.; Kim, S.J.; Kim, J.B.; Han, N.S.; Koo, B.S.; Yoon, S.H.
Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome
Biochem. Biophys. Res. Commun.
370
322-326
2008
uncultured soil bacterium (Q09PG8), uncultured soil bacterium
Manually annotated by BRENDA team
Loprasert, S.; Whangsuk, W.; Dubbs, J.M.; Sallabhan, R.; Somsongkul, K.; Mongkolsuk, S.
HpdR is a transcriptional activator of Sinorhizobium meliloti hpdA, which encodes a herbicide-targeted 4-hydroxyphenylpyruvate dioxygenase
J. Bacteriol.
189
3660-3664
2007
Sinorhizobium meliloti
Manually annotated by BRENDA team
Yang, H.; Wang, L.; Xie, Z.; Tian, Y.; Liu, G.; Tan, H.
The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negatively autoregulated and repressed by HpdR
Mol. Microbiol.
65
1064-1077
2007
Streptomyces coelicolor
Manually annotated by BRENDA team
Grossmann, K.; Ehrhardt, T.
On the mechanism of action and selectivity of the corn herbicide topramezone: a new inhibitor of 4-hydroxyphenylpyruvate dioxygenase
Pest Manag. Sci.
63
429-439
2007
Setaria faberi
Manually annotated by BRENDA team
Dayan, F.E.; Duke, S.O.; Sauldubois, A.; Singh, N.; McCurdy, C.; Cantrell, C.
p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium
Phytochemistry
68
2004-2014
2007
Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Crowell, E.F.; McGrath, J.M.; Douches, D.S.
Accumulation of vitamin E in potato (Solanum tuberosum) tubers
Transgenic Res.
17
205-217
2008
Arabidopsis thaliana
Manually annotated by BRENDA team
Molchanov, S.; Gryff-Keller, A.
Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione
Acta Biochim. Pol.
56
447-454
2009
Pseudomonas fluorescens
Manually annotated by BRENDA team
Liang, Y.; Minami, H.; Sato, F.
Isolation of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells
Biosci. Biotechnol. Biochem.
72
3059-3062
2008
Coptis japonica var. dissecta (A7BG64)
Manually annotated by BRENDA team
He, P.; Moran, G.R.
We two alone will sing: the two-substrate alpha-keto acid-dependent oxygenases
Curr. Opin. Chem. Biol.
13
436-443
2009
Pseudomonas fluorescens (P80064)
Manually annotated by BRENDA team
Turick, C.E.; Beliaev, A.S.; Zakrajsek, B.A.; Reardon, C.L.; Lowy, D.A.; Poppy, T.E.; Maloney, A.; Ekechukwu, A.A.
The role of 4-hydroxyphenylpyruvate dioxygenase in enhancement of solid-phase electron transfer by Shewanella oneidensis MR-1
FEMS Microbiol. Ecol.
68
223-225
2009
Shewanella oneidensis (Q8EFK9), Shewanella oneidensis, Shewanella oneidensis MR-1 / ATCC 700550 (Q8EFK9)
Manually annotated by BRENDA team
Dayan, F.E.; Singh, N.; McCurdy, C.R.; Godfrey, C.A.; Larsen, L.; Weavers, R.T.; Van Klink, J.W.; Perry, N.B.
Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions
J. Agric. Food Chem.
57
5194-5200
2009
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Xiao, Y.; Di, P.; Chen, J.; Liu, Y.; Chen, W.; Zhang, L.
Characterization and expression profiling of 4-hydroxyphenylpyruvate dioxygenase gene (Smhppd) from Salvia miltiorrhiza hairy root cultures
Mol. Biol. Rep.
36
2019-2029
2009
Salvia miltiorrhiza (C7S313), Salvia miltiorrhiza
Manually annotated by BRENDA team
Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
Manually annotated by BRENDA team
Shah, D.D.; Conrad, J.A.; Heinz, B.; Brownlee, J.M.; Moran, G.R.
Evidence for the mechanism of hydroxylation by 4-hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase from intermediate partitioning in active site variants
Biochemistry
50
7694-7704
2011
Streptomyces avermitilis
Manually annotated by BRENDA team
Shah, D.; Conrad, J.; Moran, G.
Intermediate partitioning kinetic isotope effects for the NIH shift of 4-hydroxyphenylpyruvate dioxygenase and the hydroxylation reaction of hydroxymandelate synthase reveal mechanistic complexity
Biochemistry
52
6097-6107
2013
Streptomyces avermitilis
Manually annotated by BRENDA team
Raspail, C.; Graindorge, M.; Moreau, Y.; Crouzy, S.; Lefebvre, B.; Robin, A.Y.; Dumas, R.; Matringe, M.
4-hydroxyphenylpyruvate dioxygenase catalysis: identification of catalytic residues and production of a hydroxylated intermediate shared with a structurally unrelated enzyme
J. Biol. Chem.
286
26061-26070
2011
Arabidopsis thaliana, Daucus carota, Pseudomonas fluorescens, Streptomyces avermitilis
Manually annotated by BRENDA team
Lin, J.F.; Sheih, Y.L.; Chang, T.C.; Chang, N.Y.; Chang, C.W.; Shen, C.P.; Lee, H.J.
The interactions in the carboxyl terminus of human 4-hydroxyphenylpyruvate dioxygenase are critical to mediate the conformation of the final helix and the tail to shield the active site for catalysis
PLoS ONE
8
e69733
2013
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Frick, E.; Spatzal, T.; Gerhardt, S.; Krämer, A.; Einsle, O.; Hüttel, W.
Structural and functional characterization of 4-hydroxyphenylpyruvate dioxygenase from the thermoacidophilic archaeon Picrophilus torridus
Extremophiles
18
641-651
2014
Picrophilus torridus (Q6KZ98), Picrophilus torridus, Picrophilus torridus DSM 9790 (Q6KZ98)
Manually annotated by BRENDA team
Bally, J.; Job, C.; Belghazi, M.; Job, D.
Metabolic adaptation in transplastomic plants massively accumulating recombinant proteins
PLoS ONE
6
e25289
2011
Pseudomonas fluorescens
Manually annotated by BRENDA team
Rocaboy-Faquet, E.; Noguer, T.; Romdhane, S.; Bertrand, C.; Dayan, F.E.; Barthelmebs, L.
Novel bacterial bioassay for a high-throughput screening of 4-hydroxyphenylpyruvate dioxygenase inhibitors
Appl. Microbiol. Biotechnol.
98
7243-7252
2014
Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Moran, G.
4-Hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase exemplars of the alpha-keto acid dependent oxygenases
Arch. Biochem. Biophys.
544
58-68
2014
Pseudomonas fluorescens, Paracoccidioides brasiliensis, Homo sapiens (P32754), Arabidopsis thaliana (P93836), Streptomyces avermitilis (Q53586), Streptomyces avermitilis ATCC 31267 (Q53586)
Manually annotated by BRENDA team
Salerno, C.; Zicari, A.; Mari, E.; D'Eufemia, P.
Scavenging properties of neutrophil 4-hydroxyphenylpyruvate dioxygenase are based on a hypothesis that does not stand up to scrutiny
Biomed. Pharmacother.
68
1045-1048
2014
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Xu, Y.L.; Lin, H.Y.; Cao, R.J.; Ming, Z.Z.; Yang, W.C.; Yang, G.F.
Pyrazolone-quinazolone hybrids a novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors
Bioorg. Med. Chem.
22
5194-5211
2014
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Xu, Y.L.; Lin, H.Y.; Ruan, X.; Yang, S.G.; Hao, G.F.; Yang, W.C.; Yang, G.F.
Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-hydroxyphenylpyruvate dioxygenase inhibitors
Eur. J. Med. Chem.
92
427-438
2015
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Garcia, P.; Moreau, A.; Ierich, J.; Vig, A.; Higa, A.; Oliveira, G.; Abdalla, F.; Hausen, M.; Leite, F.
A nanobiosensor based on 4-hydroxyphenylpyruvate dioxygenase enzyme for mesotrione detection
IEEE Sens. J.
15
2106-2113
2015
Homo sapiens (P32754)
-
Manually annotated by BRENDA team
Kramer, C.M.; Launis, K.L.; Traber, M.G.; Ward, D.P.
Vitamin E levels in soybean (Glycine max (L.) Merr.) expressing a p-hydroxyphenylpyruvate gene from oat (Avena sativa L.)
J. Agric. Food Chem.
62
3453-3457
2014
Avena sativa
Manually annotated by BRENDA team
Wang, D.W.; Lin, H.Y.; Cao, R.J.; Chen, T.; Wu, F.X.; Hao, G.F.; Chen, Q.; Yang, W.C.; Yang, G.F.
Synthesis and herbicidal activity of triketone-quinoline hybrids as novel 4-hydroxyphenylpyruvate dioxygenase inhibitors
J. Agric. Food Chem.
63
5587-5596
2015
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Wang, D.W.; Lin, H.Y.; He, B.; Wu, F.X.; Chen, T.; Chen, Q.; Yang, W.C.; Yang, G.F.
An efficient one-pot synthesis of 2-(aryloxyacetyl)cyclohexane-1,3-diones as herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors
J. Agric. Food Chem.
64
8986-8993
2016
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Wojcik, A.; Broclawik, E.; Siegbahn, P.E.; Lundberg, M.; Moran, G.; Borowski, T.
Role of substrate positioning in the catalytic reaction of 4-hydroxyphenylpyruvate dioxygenase - a QM/MM study
J. Am. Chem. Soc.
136
14472-14485
2014
Pseudomonas fluorescens, Pseudomonas fluorescens ATCC 13525
Manually annotated by BRENDA team
Silva, T.; Dos Santos Pires, M.; De Castro, A.; Da Cunha, E.; Caetano, M.; Ramalho, T.
Molecular insight into the inhibition mechanism of plant and rat 4-hydroxyphenylpyruvate dioxygenase by molecular docking and DFT calculations
Med. Chem. Res.
24
3958-3971
2015
Rattus norvegicus (P32755), Arabidopsis thaliana (P93836)
-
Manually annotated by BRENDA team
Wang, D.W.; Lin, H.Y.; Cao, R.J.; Ming, Z.Z.; Chen, T.; Hao, G.F.; Yang, W.C.; Yang, G.F.
Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors
Pest Manag. Sci.
71
1122-1132
2015
Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Chiari, M.E.; Tosoni, L.; Joray, M.B.; Diaz Napal, G.N.; Palacios, S.M.; Ruiz, G.M.; Vera, D.M.; Carpinella, M.C.
The inhibitory activity of plants from central Argentina on p-hydroxyphenylpyruvate dioxygenase. Isolation and mechanism of inhibition of a flavanone from Flourensia oolepis
Planta Med.
81
1382-1391
2015
Sus scrofa
Manually annotated by BRENDA team
Jiang, J.; Chen, Z.; Ban, L.; Wu, Y.; Huang, J.; Chu, J.; Fang, S.; Wang, Z.; Gao, H.; Wang, X.
p-Hydroxyphenylpyruvate dioxygenase from Medicago sativa is involved in vitamin E biosynthesis and abscisic acid-mediated seed germination
Sci. Rep.
7
40625
2017
Medicago sativa (A0A1S5V3J7), Medicago sativa
Manually annotated by BRENDA team
Qiao, Y.; Wang, J.; Wang, H.; Chai, B.; Rao, C.; Chen, X.; Du, S.
4-Hydroxyphenylpyruvate dioxygenase thermolability is responsible for temperature-dependent melanogenesis in Aeromonas salmonicida subsp. salmonicida
Appl. Environ. Microbiol.
85
e01926
2019
Aeromonas salmonicida subsp. salmonicida (A0A6N4CSS6), Aeromonas salmonicida subsp. salmonicida
Manually annotated by BRENDA team
Seo, D.; Choi, K.
Heterologous production of pyomelanin biopolymer using 4-hydroxyphenylpyruvate dioxygenase isolated from Ralstonia pickettii in Escherichia coli
Biochem. Eng. J.
157
107548
2020
Ralstonia pickettii
-
Manually annotated by BRENDA team
Huang, C.W.; Hwang, C.C.; Chang, Y.L.; Liu, J.T.; Wu, S.P.; Huang, K.L.; Huang, W.M.; Lee, H.J.
Functional role of residues involved in substrate binding of human 4-hydroxyphenylpyruvate dioxygenase
Biochem. J.
478
2201-2215
2021
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Shan, C.; Lu, Z.; Li, Z.; Sheng, H.; Fan, J.; Qi, Q.; Liu, S.; Zhang, S.
4-Hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis
Cell Death Dis.
10
525
2019
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Wang, H.; Liu, B.; Lei, P.; Zhu, J.; Chen, L.; He, Q.; He, J.
Improving the herbicide resistance of 4-hydroxyphenylpyruvate dioxygenase SpHPPD by directed evolution
Enzyme Microb. Technol.
154
109964
2022
Sphingobium sp. TPM-19
Manually annotated by BRENDA team
Ndikuryayo, F.; Kang, W.M.; Wu, F.X.; Yang, W.C.; Yang, G.F.
Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors
Eur. J. Med. Chem.
166
22-31
2019
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Liu, Y.; Zhao, L.; Ye, T.; Gao, S.; Li, J.; Ye, F.; Fu, Y.
Identification of key residues determining the binding specificity of human 4-hydroxyphenylpyruvate dioxygenase
Eur. J. Pharm. Sci.
154
105504
2020
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Lin, H.Y.; Yang, J.F.; Wang, D.W.; Hao, G.F.; Dong, J.Q.; Wang, Y.X.; Yang, W.C.; Wu, J.W.; Zhan, C.G.; Yang, G.F.
Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition enzyme kinetics, X-ray crystallography and computational simulations
FEBS J.
286
975-990
2019
Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Fu, Y.; Sun, Y.N.; Yi, K.H.; Li, M.Q.; Cao, H.F.; Li, J.Z.; Ye, F.
Combination of virtual screening protocol by in silico toward the discovery of novel 4-hydroxyphenylpyruvate dioxygenase inhibitors
Front. Chem.
6
14
2018
Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Fu, Y.; Liu, Y.X.; Yi, K.H.; Li, M.Q.; Li, J.Z.; Ye, F.
Quantitative structure activity relationship studies and molecular dynamics simulations of 2-(aryloxyacetyl)cyclohexane-1,3-diones derivatives as 4-hydroxyphenylpyruvate dioxygenase inhibitors
Front. Chem.
7
556
2019
Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Singh, D.; Kumar, J.; Kumar, A.
Isolation of pyomelanin from bacteria and evidences showing its synthesis by 4-hydroxyphenylpyruvate dioxygenase enzyme encoded by hppD gene
Int. J. Biol. Macromol.
119
864-873
2018
Enterobacter sp., Klebsiella pneumoniae (A0A291P182), Klebsiella pneumoniae, Alcaligenes faecalis (A0A411SY43), Alcaligenes faecalis
Manually annotated by BRENDA team
Bolognese, F.; Scanferla, C.; Caruso, E.; Orlandi, V.T.
Bacterial melanin production by heterologous expression of 4'hydroxyphenylpyruvate dioxygenase from Pseudomonas aeruginosa
Int. J. Biol. Macromol.
133
1072-1080
2019
Pseudomonas aeruginosa (Q9I576)
Manually annotated by BRENDA team
He, B.; Dong, J.; Lin, H.; Wang, M.; Li, X.; Zheng, B.; Chen, Q.; Hao, G.; Yang, W.; Yang, G.
Pyrazole-isoindoline-1,3-dione hybrid A promising scaffold for 4-hydroxyphenylpyruvate dioxygenase inhibitors
J. Agric. Food Chem.
67
10844-10852
2019
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Fu, Y.; Zhang, D.; Zhang, S.Q.; Liu, Y.X.; Guo, Y.Y.; Wang, M.X.; Gao, S.; Zhao, L.X.; Ye, F.
Discovery of N-aroyl diketone/triketone derivatives as novel 4-hydroxyphenylpyruvate dioxygenase inhibiting-based herbicides
J. Agric. Food Chem.
67
11839-11847
2019
Arabidopsis thaliana, Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Liu, B.; Peng, Q.; Sheng, M.; Ni, H.; Xiao, X.; Tao, Q.; He, Q.; He, J.
Isolation and characterization of a topramezone-resistant 4-hydroxyphenylpyruvate dioxygenase from Sphingobium sp. TPM-19
J. Agric. Food Chem.
68
1022-1029
2020
Sphingobium sp. (A0A6B9L0W0)
Manually annotated by BRENDA team
Nan, J.X.; Yang, J.F.; Lin, H.Y.; Yan, Y.C.; Zhou, S.M.; Wei, X.F.; Chen, Q.; Yang, W.C.; Qu, R.Y.; Yang, G.F.
Synthesis and herbicidal activity of triketone-aminopyridines as potent p-hydroxyphenylpyruvate dioxygenase inhibitors
J. Agric. Food Chem.
69
5734-5745
2021
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Feng, A.N.; Huang, C.W.; Lin, C.H.; Chang, Y.L.; Ni, M.Y.; Lee, H.J.
Role of the N-terminus in human 4-hydroxyphenylpyruvate dioxygenase activity
J. Biochem.
167
315-322
2020
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team
Liang, W.; Zhang, W.; Shao, Y.; Zhao, X.; Li, C.
Dual functions of a 4-hydroxyphenylpyruvate dioxygenase for Vibrio splendidus survival and infection
Microb. Pathog.
120
47-54
2018
Vibrio splendidus
Manually annotated by BRENDA team
Huang, H.; Zhang, J.Q.; Liu, J.M.; Wang, M.M.; Shu, L.; Yan, Y.L.; Zhan, X.H.; Wang, P.; Huan, X.T.; Zhang, D.Y.
Discovery of novel benzofuran scaffold as 4-hydroxyphenylpyruvate dioxygenase inhibitors
Pest Manag. Sci.
77
1409-1421
2021
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Hawkes, T.R.; Langford, M.P.; Viner, R.; Blain, R.E.; Callaghan, F.M.; Mackay, E.A.; Hogg, B.V.; Singh, S.; Dale, R.P.
Characterization of 4-hydroxyphenylpyruvate dioxygenases, inhibition by herbicides and engineering for herbicide tolerance in crops
Pestic. Biochem. Physiol.
156
9-28
2019
Avena sativa, Arabidopsis thaliana (P93836)
Manually annotated by BRENDA team
Kohlhase, D.R.; Edwards, J.W.; Owen, M.D.K.
Inheritance of 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide resistance in an Amaranthus tuberculatus population from Iowa, USA
Plant Sci.
274
360-368
2018
Amaranthus tuberculatus
Manually annotated by BRENDA team
Schindler, C.E.M.; Hollenbach, E.; Mietzner, T.; Schleifer, K.J.; Zacharias, M.
Free energy calculations elucidate substrate binding, gating mechanism, and tolerance-promoting mutations in herbicide target 4-hydroxyphenylpyruvate dioxygenase
Protein Sci.
28
1048-1058
2019
Zea mays, Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Dreesen, R.; Capt, A.; Oberdoerfer, R.; Coats, I.; Pallett, K.E.
Characterization and safety evaluation of HPPD W336, a modified 4-hydroxyphenylpyruvate dioxygenase protein, and the impact of its expression on plant metabolism in herbicide-tolerant MST-FGO72-2 soybean
Regul. Toxicol. Pharmacol.
97
170-185
2018
Pseudomonas fluorescens, Pseudomonas fluorescens A32
Manually annotated by BRENDA team
Lin, H.; Chen, X.; Chen, J.; Wang, D.; Wu, F.; Lin, S.; Zhan, C.; Wu, J.; Yang, W.; Yang, G.
Crystal structure of 4-hydroxyphenylpyruvate dioxygenase in complex with substrate reveals a new starting point for herbicide discovery
Research (Wash. D.C.)
2019
2602414
2019
Arabidopsis thaliana (P93836), Arabidopsis thaliana
Manually annotated by BRENDA team
Neuckermans, J.; Mertens, A.; De Win, D.; Schwaneberg, U.; De Kock, J.
A robust bacterial assay for high-throughput screening of human 4-hydroxyphenylpyruvate dioxygenase inhibitors
Sci. Rep.
9
14145
2019
Homo sapiens (P32754), Homo sapiens
Manually annotated by BRENDA team