1.13.11.20: cysteine dioxygenase
This is an abbreviated version!
For detailed information about cysteine dioxygenase, go to the full flat file.
Word Map on EC 1.13.11.20
-
1.13.11.20
-
taurine
-
sulfinic
-
non-heme
-
hypotaurine
-
cysteinesulfinate
-
cysteamine
-
cystathionine
-
3-mercaptopropionate
-
cys-tyr
-
taut
-
adenosyltransferase
-
desulfhydration
-
2-his-1-carboxylate
-
gamma-lyase
-
cupins
-
2-aminoethanethiol
-
medicine
- 1.13.11.20
- taurine
-
sulfinic
-
non-heme
- hypotaurine
-
cysteinesulfinate
- cysteamine
- cystathionine
- 3-mercaptopropionate
-
cys-tyr
-
taut
-
adenosyltransferase
-
desulfhydration
-
2-his-1-carboxylate
-
gamma-lyase
-
cupins
- 2-aminoethanethiol
- medicine
Reaction
Synonyms
3-mercaptopropionate dioxygenase, 3MDO, ADO, Arg-type CDO, BsCDO, CDO, CDO1, CDO2, CdoA, CdoB, cysteine dioxygenase, cysteine dioxygenase type 1, cysteine oxidase, Fe(II) cysteine dioxygenase, H16_A1614, H16_B1863, NP_251292, oxygenase, cysteine di-, PA2602, PCO1, PCO4
ECTree
1.13.11.20 cysteine dioxygenaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 1.13.11.20 - cysteine dioxygenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
beta-mercaptoethanol + O2
2-hydroxyethanesulfinate
-
slight activity
-
?
H2N-CGGAIISDFI-COOH + O2
H2N-(sulfino-Cys)-GGAIISDFI-COOH + H2N-(sulfono-Cys)-GGAIISDFI-COOH
synthetic 10-mer peptide corresponding to the methionine excised N termini of the ERF-VIIs RAP2.2, RAP2.12 and HRE2
-
-
?
N-terminal Cys of RGS4 + O2
N-terminal Cys-sulfinic acid of RGS4
i.e. regulator of G-protein signalling
-
-
?
N-terminal Cys of RGS5 + O2
N-terminal Cys-sulfinic acid of RGS5
i.e. regulator of G-protein signalling
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
-
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
-
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropanoate + O2
3-sulfinopropanoate + H+
reaction of EC 1.13.11.91
-
-
?
3-mercaptopropionate + O2
3-sulfinopropionate
3fold higher activity compared to L-cysteine. 3-Mercaptopropionate does not occur naturally in cells of strain H16
-
-
?
3-mercaptopropionate + O2
3-sulfinopropionate
3fold higher activity compared to L-cysteine. 3-Mercaptopropionate does not occur naturally in cells of strain H16
-
-
?
3-mercaptopropionate + O2
3-sulfinopropionate
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
3fold higher activity compared to L-cysteine. 3-Mercaptopropionate does not occur naturally in cells of strain H16
-
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
highly specific for L-cysteine
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
probable role in the mycelial to yeast phase transition
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
key enzyme in sulfate production, involved in the production of sulfate for the maintenance of a metabolic barrier against the entry of airborne xenobiotics and protein synthesis
-
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
-
-
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
highly specific for L-cysteine
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
highly specific for L-cysteine
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
key enzyme of cysteine metabolism
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
key enzyme of cysteine metabolism
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
liver enzyme responds to dietary protein contents, role in regulation of intracellular levels of methionine, cysteine and glutathione
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
enzyme expression in the brain may have several possible functions, like the prevention of free radical production by the autooxidation of cysteine and dopamine
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
key enzyme in sulfate production, critical regulator of cellular cysteine concentration and availability of cysteine for anabolic processes
-
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
key enzyme of cysteine catabolism, supplies substrate for taurine biosynthesis
-
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
key enzyme of taurine biosynthesis, provides substrate for transamination, regulation of intracellular cysteine level
-
-
?
L-cysteine + O2
3-sulfino-L-alanine
-
regulation of intracellular cysteine concentration
-
-
?
L-cysteine + O2
3-sulfinoalanine
structure of the sulfinato complex, overview
-
-
?
L-cysteine + O2
3-sulfinoalanine
-
-
-
?
L-cysteine + O2
3-sulfinoalanine
anaerobic CDO reaction conditions
-
-
?
L-cysteine + O2
3-sulfinoalanine
enzyme CDO-L-cysteine complex structure analysis and modeling, O2 binding structure, QM-MM simulations, detailed overview
-
-
?
additional information
?
-
-
enzyme exhibits a specificity for 3-mercaptopropanoate nearly 2 orders of magnitude greater than those for cysteine
-
-
-
additional information
?
-
no activity with 3-mercaptopropionate by CdoB
-
-
?
additional information
?
-
no activity with 3-mercaptopropionate by CdoB
-
-
?
additional information
?
-
3-mercaptopropanoate is preferred over cysteine. No substrate: cysteamine
-
-
-
additional information
?
-
3-mercaptopropanoate is preferred over cysteine. No substrate: cysteamine
-
-
-
additional information
?
-
3-mercaptopropanoate is preferred over cysteine. No substrate: cysteamine
-
-
-
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
3-mercaptopropanoate is preferred over cysteine. No substrate: cysteamine
-
-
-
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
3-mercaptopropanoate is preferred over cysteine. No substrate: cysteamine
-
-
-
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
no activity with 3-mercaptopropionate by CdoB
-
-
?
additional information
?
-
Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
no activity with 3-mercaptopropionate by CdoB
-
-
?
additional information
?
-
-
D-cysteine, cystine, taurine, cystamine, cysteinesulfinic acid, glutathione, cysteic acid, S-methylcysteine and pyruvic acid do not serve as substrates
-
-
?
additional information
?
-
prediction of a h2-O,O-binding mode for synthetic as well as the natural enzyme, modeling of the cysteine sulfinic product complex in the active site
-
-
?
additional information
?
-
enzyme is able to cleave C-F bonds. The oxidants produced at the center of the non-heme ferrite effectively oxidize adjacent coordination residues and oxidize C-Cl and even C-F bonds during the formation of dihalogen-substituted cofactors, via four elementary steps: H-abstraction, C-S bond formation, F-transfer, and C-F bond cleavage. C-F bond cleavage is the rate-determining step with an energy barrier of 18.8 kcal/mol
-
-
-
additional information
?
-
-
cysteine dioxygenase and methionine sulfoxide reductase are working in coordination to balance cellular antioxidant level
-
-
?
additional information
?
-
-
CDO cannot catalyze the oxidation of selenocysteine
-
-
?
additional information
?
-
-
CDO exhibits high specificity for L-cysteine, displaying little or no reactivity with D-cysteine, glutathione, L-cystine, or cysteamine
-
-
?
additional information
?
-
recombinant 3MDO is able to oxidize both cysteine and 3-mercaptopropionic acid in vitro, with a marked preference for 3-mercaptopropionic acid. Substrate binding to the ferrous iron is through the thiol but each substrate may adopt different coordination geometries
-
-
-
additional information
?
-
-
recombinant 3MDO is able to oxidize both cysteine and 3-mercaptopropionic acid in vitro, with a marked preference for 3-mercaptopropionic acid. Substrate binding to the ferrous iron is through the thiol but each substrate may adopt different coordination geometries
-
-
-
additional information
?
-
recombinant 3MDO is able to oxidize both cysteine and 3-mercaptopropionic acid in vitro, with a marked preference for 3-mercaptopropionic acid. Substrate binding to the ferrous iron is through the thiol but each substrate may adopt different coordination geometries
-
-
-
additional information
?
-
-
glutathione, dithiothreitol and cystine do not serve as substrates
-
-
?
additional information
?
-
-
L-cystine, D-cysteine, DL-homocysteine and cysteamine do not serve as substrates
-
-
?
additional information
?
-
-
L-cystine, D-cysteine, carboxymethyl-L-cysteine, carboxyethyl-L-cysteine, S-methyl-L-cysteine, N-acetyl-L-cysteine, DL-homocysteine and cysteamine do not serve as substrates
-
-
?
additional information
?
-
-
cysteamine does not serve as substrate, D-cysteine does not serve as substrate
-
-
?
additional information
?
-
-
cysteine catabolism in mammals is dependent upon cysteine dioxygenase. System for regulation of cellular cysteine levels. Evidence of abnormal or deficient CDO activity has been reported in individuals with a variety of autoimmune and neurodegenerative diseases, including rheumatoid arthritis, Parkinsons disease, Alzheimers disease, and motor neuron diseases
-
-
?
additional information
?
-
-
cysteine dioxygenase cannot catalyze the oxidation of selenocysteine. In the Cys-bound complexes, the change of the oxidation state for the Fe center is II to III to II, while the Fe center in the Sec-bound complexes remains in the II oxidation state throughout. The competition for donation of electron density with the iron ion determines the valence change and the reaction ability
-
-
?
additional information
?
-
formation of an active CDO:cysteine substrate complex
-
-
?
additional information
?
-
homocysteine and D-Cys are no substrates
-
-
?
