1.13.11.12: linoleate 13S-lipoxygenase

This is an abbreviated version!
For detailed information about linoleate 13S-lipoxygenase, go to the full flat file.

Word Map on EC 1.13.11.12

1.13.11.12

arachidonic

cyclooxygenase

leukotriene

prostaglandin

indomethacin

linoleic

nordihydroguaiaretic

eicosanoids

phospholipase

platelet

thromboxane

hydroperoxide

leukocyte

polyunsaturated

phospholipid

ndga

hetes

neutrophil

artery

12-hete

ionophore

polymorphonuclear

lipoxins

radioimmunoassay

paf

cox-2

oxylipins

prostacyclin

jasmonic

docosahexaenoic

eicosapentaenoic

histamine

aspirin

platelet-activating

epoxyeicosatrienoic

bronchoconstriction

endoperoxide

quinacrine

6-keto-pgf1

6-keto-prostaglandin

medicine

food industry

synthesis

prostanoids

aa-induced

baicalein

piroxicam

mepacrine

vasoconstriction

epoxygenase

ibuprofen

meclofenamate

zymosan

biotechnology

Reaction

(9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate

Synonyms

(13S)-lipoxygenase, 13-lipoxygenase, 13-LOX, 13S-lipoxygenase, 15-lipoxygenase-1, 15-LOX-1, 9/13-LOX, acidic lipoxygenase, Alox15, arachidonic acid 15S-lipoxygenating enzyme, AtLOX-2, AtLOX-3, AtLOX-4, AtLOX-6, CmLOX10, CmLOX13, iron 13S-lipoxygenase, liipoxygenase, linoleate 13-lipoxygenase, linoleate 13S-lipoxygenase, linoleate oxygen oxidoreductase, linoleate: oxygen oxidoreductase, linoleate:oxygen oxidoreductase, lipoxygenase, lipoxygenase 2, lipoxygenase-1, lipoxygenase-2, lipoxygenase-3, lipoxygenase-4, lipoxygenase-6, LO-1, LOX, LOX-1, LOX-2, LOX1, LOX10, LOX11, LOX12, LOX2, LOX2:Hv:1, LOX2:Md:2b, LOX2b, LOX3, LOX4, LOX6, LOX7, LOX8, LOX9, LoxA, Lpx-A2, MSD2, Oep1LOX2, Oep2LOX2, omega-6 linoleate lipoxygenase, PA-LOX, RCI-1, SBLO-1, secreted lipoxygenase, SLO, soybean lipoxygenase-1, StLOX2, StLOX3, type-1 LOX, type-2 13-LOX

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.12 linoleate 13S-lipoxygenase

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Results	in table
2	Activating Compound
107	AA Sequence
15	Application
1	CAS Registry Number
30	Cloned(Commentary)
1	Crystallization (Commentary)
3835	Disease/ Diagnostics
18	Expression
35	General Information
109	IC50 Value
175	Inhibitors
18	kcat/KM [mM/s]
23	Ki Value [mM]
63	KM Value [mM]
20	Localization
32	Metals/Ions
15	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
85	Organism
9	Pathway
44	PDB ID
27	pH Optimum
16	pH Range
2	pH Stability
6	pI Value
6	Protein Variants
21	Purification (Commentary)
3	Reaction
3	Reaction Type
69	Reference
51	Source Tissue
14	Specific Activity [micromol/min/mg]
1	Storage Stability
147	Substrates and Products (Substrate)
28	Subunits
155	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
17	Temperature Range [°C]
4	Temperature Stability [°C]
23	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 1.13.11.12 - linoleate 13S-lipoxygenase

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4.5 - 8.5

broad optimum with a maximum at pH 8.0, substrate: linoleate

4.8

Cucumis melo var. makuwa

A0A125S6K7, A0A125S6K8

743601

5.5

Cucumis melo var. makuwa

A0A125S6K7, A0A125S6K8

6.25

isoform Oep1LOX2

6.3

isoenzyme Oep2LOX2

6.75

isoform Oep2LOX2

6.8

isoenzyme Oep1LOX2

7 - 9

linoleic acid is a considerably better substrate for SBLO-1 at pH 9.0 than at pH 7.0, while the activity with linoleyltrimethylammonium ion is the same at pH 7.0 and pH 9.0

724511

7.2

Cucumis sativus

triolein as substrate

7.5

8.8

for linoleic acid

702672, 704118, 706929

9.5

Glycine max

764604