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1.11.1.9: glutathione peroxidase

This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.9

Reaction

2 glutathione +

H2O2
=
glutathione disulfide
+ 2 H2O

Synonyms

2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.9 glutathione peroxidase

Specific Activity

Specific Activity on EC 1.11.1.9 - glutathione peroxidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.013
-
crude enzyme, at 25°C
0.07
-
cholesterol 5alpha-hydroperoxide
0.1
-
cholesterol 7beta-hydroperoxide
0.13
-
linolenic acid hydroperoxide
0.16
-
L-alpha-phosphatidylcholine hydroperoxide
0.18
-
cholesterol 7alpha-hydroperoxide
0.24
mutant enzyme N136A, using thioredoxin and phosphatidylcholine hydroperoxide as substrates
0.4
mutant enzyme N136H, using thioredoxin and phosphatidylcholine hydroperoxide as substrates
0.52
wild-type, pH 7.4, 37°C
1.462
-
after 112.46fold purification, at 25°C
11.9
-
U2-OS treated with etoposide
12.09
-
pH 7, 37°C
120
-
subcellular fractionation
1300
-
plasma membrane
14.38
wild type enzyme, using thioredoxin and phosphatidylcholine hydroperoxide as substrates
1407
-
-
25
mutant with all Cys residues changed to Ser, substrate H2O2, pH 7.4, 37°C
281
-
outer mitochondrial membrane
337
-
inner mitochondrial membrane
350
-
-
4.29
mutant enzyme N40A, using thioredoxin and phosphatidylcholine hydroperoxide as substrates
402
-
linolenic acid hydroperoxide
408
-
linoleic acid hydroperoxide
42.2
-
isoform Gpx2, pH 7.0, 25°C
472
-
cumene hydroperoxide
5
-
Saos-2
5.28
mutant C2S/C78S/C115S/C156S/C202S, pH 7.4, 37°C
5.5
-
Saos-2 treated with etoposide
5.81
mutant enzyme C74A, using thioredoxin and phosphatidylcholine hydroperoxide as substrates
511
-
arachidonic acid 15-hydroperoxide
56.3
-
isoform Gpx1, pH 7.0, 25°C
6.7
-
U2-OS
8.5
mutant with all Cys residues changed to Ser, substrate 1-palmitoyl-2-(13-hydroperoxy-cis-9, trans-11-octadecadienoyl)-L-3-phosphatidylcholine, pH 7.4, 37°C
84.3
substrate cumene hydroperoxide, 37°C, pH 7.6